NRG-BR001
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RTOG
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A Phase 1 Study of Stereotactic Body Radiotherapy (SBRT) for the Treatment of Multiple Metastases
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Adult CIRB - Early Phase Emphasis
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Completed
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NRG-BR002
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NRG
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A Phase IIR/III Trial of Standard of Care Therapy with or without Stereotactic Body Radiotherapy (SBRT) and/or Surgical Ablation for Newly Oligometastatic Breast Cancer
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Adult CIRB - Late Phase Emphasis
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Available to Open
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NRG-BR003
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NRG
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A Randomized Phase III Trial of Adjuvant Therapy Comparing Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel with or without Carboplatin for Node-Positive or High-Risk Node-Negative Triple-Negative Invasive Breast Cancer
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Adult CIRB - Late Phase Emphasis
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Available to Open
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NRG-BR004
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NRG
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A Randomized, Double-Blind, Phase III Trial of Paclitaxel/Trastuzumab/Pertuzumab with Atezolizumab or Placebo in First-Line HER2-Positive Metastatic Breast Cancer
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Adult CIRB - Late Phase Emphasis
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Available to Open
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NRG-BR005
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NRG
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A Phase II Trial Assessing the Accuracy of Tumor Bed Biopsies in Predicting Pathologic Response in Patients with Clinical/Radiologic Complete Response after Neoadjuvant Chemotherapy in Order to Explore the Feasibility of Breast Conserving Treatment without Surgery
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Adult CIRB - Late Phase Emphasis
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Completed
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NRG-BR007
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NRG
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A Phase III Clinical Trial Evaluating De-Escalation of Breast Radiation for Conservative Treatment of Stage I, Hormone Sensitive, HER2-Negative, Oncotype Recurrence Score ≤18 Breast Cancer
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Adult CIRB - Late Phase Emphasis
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Available to Open
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NRG-BR008
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NRG
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Phase III Randomized Trial of Radiotherapy Optimization for Low-Risk HER2-Positive Breast Cancer (HERO)
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Adult CIRB - Late Phase Emphasis
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Available to Open
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NRG-BR009
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NRG
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A Phase III Adjuvant Trial Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression plus Endocrine Therapy in Premenopausal Patients with pN0-1, ER Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score ≤ 25 (OFSET)
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Adult CIRB - Late Phase Emphasis
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Available to Open
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NRG-CC001
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NRG
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A Randomized Phase III Trial Of Memantine And Whole-Brain Radiotherapy With Or Without Hippocampal Avoidance In Patients With Brain Metastases
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Cancer Prevention and Control CIRB
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Completed
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NRG-CC003
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NRG
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Randomized Phase II/III Trial of Prophylactic Cranial Irradiation with Or without Hippocampal Avoidance for Small Cell Lung Cancer
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Cancer Prevention and Control CIRB
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Available to Open
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