NRG-BN001
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NRG
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Randomized Phase II Trial of Hypofractionated Dose-Escalated Photon IMRT or Proton Beam Therapy Versus Conventional Photon Irradiation With Concomitant and Adjuvant Temozolomide in Patients With Newly Diagnosed Glioblastoma
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Adult CIRB - Late Phase Emphasis
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Available to Open
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NRG-BN002
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NRG
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Phase I Study Of Ipilimumab; Nivolumab; And The Combination In Patients With Newly Diagnosed Glioblastoma
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Adult CIRB - Early Phase Emphasis
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Completed
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NRG-BN003
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NRG
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Phase III Trial of Observation Versus Irradiation for a Gross Totally Resected Grade II Meningioma
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Adult CIRB - Late Phase Emphasis
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Available to Open
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NRG-BN005
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NRG
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A Phase II Randomized Trial of Proton vs. Photon Therapy (IMRT) for Cognitive Preservation in Patients with IDH Mutant, Low to Intermediate Grade Gliomas
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Adult CIRB - Late Phase Emphasis
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Available to Open
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NRG-BN007
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NRG
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A Randomized Phase II/III Open-Label Study of Ipilimumab and Nivolumab versus Temozolomide in Patients with Newly Diagnosed MGMT (Tumor O-6-Methylganine DNA Methyltransferase) Unmethylated Glioblastoma
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Adult CIRB - Late Phase Emphasis
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Available to Open
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NRG-BN009
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NRG
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Phase III Trial of Salvage Stereotactic Radiosurgery (SRS) or SRS + Hippocampal-Avoidant Whole Brain Radiotherapy (HA-WBRT) for First or Second Distant Brain Relapse after Upfront SRS with Brain Metastasis Velocity ≥4 Brain Metastases/Year
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Adult CIRB - Late Phase Emphasis
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Available to Open
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NRG-BN010
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NRG
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A Safety Run-In and Phase II Study Evaluating the Efficacy, Safety, and Impact on the Tumor Microenvironment of the Combination of Tocilizumab, Atezolizumab, and Fractionated Stereotactic Radiotherapy in Recurrent Glioblastoma
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Adult CIRB - Late Phase Emphasis
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Available to Open
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NRG-BN011
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NRG
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A Phase III Trial of Lomustine-Temozolomide Combination Therapy Versus Standard Temozolomide in Patients with Methylated MGMT Promoter Glioblastoma
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Adult CIRB - Late Phase Emphasis
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Available to Open
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NRG-BN012
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NRG
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A Randomized Phase III Trial of Pre-Operative Compared to Post-Operative Stereotactic Radiosurgery in Patients with Resectable Brain Metastases
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Adult CIRB - Late Phase Emphasis
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Available to Open
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NRG-BN013
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NRG
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Phase III Trial of Single Fraction Stereotactic Radiosurgery (SRS) versus Fractionated SRS (FSRS) for Intact Brain Metastases
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Adult CIRB - Late Phase Emphasis
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Available to Open
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