CIRB Studies

Below is the current list of studies covered by the CIRB. Participants should refer to ClinicalTrials.gov for general information about clinical trials. Institutions should refer to the Clinical Trials Support Unit (CTSU) website  for enrollment requirements and accrual status information. 

Study documents approved after July 1, 2013 are available to participating institutions for covered studies on the CTSU website. To request documents approved before July 1, 2013, participating institutions can contact the CIRB Helpdesk.

Review CIRB
Study Number Network Study Title CIRB
EA2205 ECOG-ACRIN A Randomized Phase II Trial Evaluating Chemotherapy vs Chemotherapy plus Bevacizumab and Atezolizumab in Advanced Combined Hepatocellular Carcinoma-Cholangiocarcinoma Adult CIRB - Late Phase Emphasis
EA2212 ECOG-ACRIN A Randomized Phase II Study of Perioperative Atezolizumab +/- Chemotherapy in Resectable MSI-H/dMMR Gastric and Gastroesophageal Junction (GEJ) Cancer Adult CIRB - Early Phase Emphasis
EA2222 ECOG-ACRIN A Randomized Phase III Study of Systemic Therapy with or without Hepatic Arterial Infusion for Unresectable Colorectal Liver Metastases: The PUMP Trial Adult CIRB - Late Phase Emphasis
EA223 ECOG-ACRIN A Randomized Phase II/III Trial of Intraperitoneal Paclitaxel Plus Systemic Treatment vs Systemic Treatment Alone in Gastric Carcinomatosis – STOPGAP II Adult CIRB - Late Phase Emphasis
EA3132 ECOG-ACRIN Phase II Randomized Trial of Radiotherapy with or without Cisplatin for Surgically Resected Squamous Cell Carcinoma of the Head and Neck (SCCHN) with TP53 Sequencing Adult CIRB - Late Phase Emphasis
EA3161 ECOG-ACRIN A Phase II/III Randomized Study of Maintenance Nivolumab versus Observation in Patients with Locally Advanced, Intermediate Risk HPV Positive OPSCC Adult CIRB - Late Phase Emphasis
EA3163 ECOG-ACRIN Phase II Randomized Trial of Neo-Adjuvant Chemotherapy followed by Surgery and Post-Operative Radiation versus Surgery and Post-Operative Radiation for Organ Preservation of T3 and T4a Nasal and Paranasal Sinus Squamous Cell Carcinoma (NPNSCC) Adult CIRB - Late Phase Emphasis
EA3191 ECOG-ACRIN A Phase II Randomized Trial of Adjuvant Therapy with Pembrolizumab after Resection of Recurrent/Second Primary Head and Neck Squamous Cell Carcinoma with High Risk Features Adult CIRB - Late Phase Emphasis
EA3202 ECOG-ACRIN A Phase II/III Trial of Chemotherapy + Cetuximab vs Chemotherapy + Bevacizumab vs Atezolizumab + Bevacizumab Following Progression on Immune Checkpoint Inhibition in Recurrent/Metastatic Head and Neck Cancers Adult CIRB - Late Phase Emphasis
EA3211 ECOG-ACRIN Phase III Randomized Trial of Immunotherapy with or without Consolidative Radiotherapy for Oligometastatic Head and Neck Squamous Cell Carcinoma Adult CIRB - Late Phase Emphasis