Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number Sort descending | Lead Group | Study Title | CIRB | Study Status | |
|---|---|---|---|---|---|
| EA6183 | ECOG-ACRIN | A Phase II Neoadjuvant Study of Encorafenib with Binimetinib in Patients with Resectable Locoregional Metastases from Cutaneous or Unknown Primary Melanoma (Stages III N1B/C/D) | Adult CIRB - Late Phase Emphasis | Available to Open | |
| EA6191 | ECOG-ACRIN | The BAMM2 (BRAF, Autophagy, MEK inhibition in Melanoma) Study: A Randomized Double Blind Phase II Study of Dabrafenib and Trametinib with or without Hydroxychloroquine in Advanced BRAF V600E/K Melanoma | Adult CIRB - Late Phase Emphasis | Available to Open | |
| EA6192 | ECOG-ACRIN | A Phase II Study of Biomarker Driven Early Discontinuation of Anti-PD-1 Therapy in Patients with Advanced Melanoma (PET-Stop) | Adult CIRB - Late Phase Emphasis | Available to Open | |
| EA6194 | ECOG-ACRIN | Phase II Randomized Study of Neoadjuvant Pembrolizumab Alone or in Combination with CMP-001 in Patients with Operable Melanoma: Efficacy and Biomarker Study | Adult CIRB - Late Phase Emphasis | Available to Open | |
| EA7211 | ECOG-ACRIN | A Randomized Phase III Study of Neoadjuvant Chemotherapy followed by Surgery versus Surgery Alone for Patients with High Risk RetroPeritoneal Sarcoma (STRASS 2) | Adult CIRB - Late Phase Emphasis | Available to Open | |
| EA7222 | ECOG-ACRIN | A Randomized Phase III Trial of Doxorubicin + Pembrolizumab Versus Doxorubicin Alone for the Treatment of Undifferentiated Pleomorphic Sarcoma (UPS) and Related Poorly Differentiated Sarcomas | Adult CIRB - Late Phase Emphasis | Available to Open | |
| EA8134 | ECOG-ACRIN | InPACT- International Penile Advanced Cancer Trial (International Rare Cancers Initiative Study) | Adult CIRB - Late Phase Emphasis | Available to Open | |
| EA8141 | ECOG-ACRIN | A Prospective Phase II Trial of Neoadjuvant Systemic Chemotherapy followed by Extirpative Surgery for Patients with High Grade Upper Tract Urothelial Carcinoma | Adult CIRB - Late Phase Emphasis | Completed | |
| EA8143 | ECOG-ACRIN | A Phase 3 RandOmized Study Comparing PERioperative Nivolumab vs. Observation in Patients with Renal Cell Carcinoma Undergoing Nephrectomy (PROSPER RCC) | Adult CIRB - Late Phase Emphasis | Available to Open | |
| EA8153 | ECOG-ACRIN | Cabazitaxel with Abiraterone versus Abiraterone alone Randomized Trial for Extensive Disease following Docetaxel: the CHAARTED2 Trial | Adult CIRB - Late Phase Emphasis | Available to Open |