Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number Sort descending | Lead Group | Study Title | CIRB | Study Status | |
|---|---|---|---|---|---|
| 10647 | ETCTN | Phase I/Ib Study of Eribulin in Combination with ASTX660 (tolinapant) in Metastatic Triple Negative Breast Cancer (TNBC) | Adult CIRB - Early Phase Emphasis | Available to Open | |
| 10657 | ETCTN | Phase I/II Study to Evaluate the Feasibility and Efficacy of Sequential Abemaciclib and Gemcitabine Treatment in Patients with Retinoblastoma (Rb)+ Sarcomas | Adult CIRB - Early Phase Emphasis | Available to Open | |
| 10667 | ETCTN | Pilot Study of Pidnarulex Pharmacodynamics in Patients with Advanced Solid Tumors | Adult CIRB - Early Phase Emphasis | Available to Open | |
| 10670 | ETCTN | A Phase 1 Study of 5-Fluorouracil in Combination with Abemaciclib in Metastatic, Refractory CRC | Adult CIRB - Early Phase Emphasis | Available to Open | |
| 10674 | ETCTN | A Phase I Study Evaluating the Safety of Cirtuvivint as Monotherapy and in Combination with ASTX727 in Patients with Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML) | Adult CIRB - Early Phase Emphasis | Available to Open | |
| 8329 | ETCTN | A Phase I/II Trial of ABT-888, an Inhibitor of Poly(ADP-ribose) Polymerase (PARP), and Topotecan (TPT) in Patients with Solid Tumors (Phase I) and Relapsed Ovarian Cancer or Primary Peritoneal Cancer (Phase II) After Prior Platinum Containing First-Line Chemotherapy | Adult CIRB - Early Phase Emphasis | Available to Open | |
| 9149 | ETCTN | Molecular Profiling-based Assignment of Cancer Therapy for Patients With Advanced Solid Tumors | Adult CIRB - Late Phase Emphasis | Available to Open | |
| 9466 | ETCTN | Phase I/II study of dabrafenib, trametinib, and navitoclax in BRAF mutant melanoma (Phase I and II) and other solid tumors (Phase I only) | Adult CIRB - Early Phase Emphasis | Available to Open | |
| 9571 | ETCTN | A phase IB study of the combination of AZD6244 hydrogen sulfate (selumetinib) and cyclosporin A (CsA) in patients with advanced solid tumors with an expansion cohort in metastatic colorectal cancer | Adult CIRB - Early Phase Emphasis | Completed | |
| 9608 | ETCTN | A Phase I Trial of ABT-263 (Navitoclax); a Bcl-2 inhibitor; and Sorafenib (Nexavar) in Patients with Relapsed or Refractory Solid Organ Tumors | Adult CIRB - Early Phase Emphasis | Available to Open |