Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number Sort descending | Lead Group | Study Title | CIRB | Study Status | |
|---|---|---|---|---|---|
| AALL2121 | COG | A Phase 2 study of SNDX-5613 in combination with chemotherapy for patients with relapsed or refractory KMT2A-rearranged infant leukemia | Pediatric CIRB | Available to Open | |
| AAML0121 | COG | "A Phase II Study of Amifostine In Children with Myelodysplastic Syndrome: A Group-wide Study" | Pediatric CIRB | Completed | |
| AAML0431 | COG | The Treatment of Down Syndrome Children with Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS) Under the Age of 4 Years: A Groupwide Phase III Study | Pediatric CIRB | Completed | |
| AAML0523 | COG | A Phase I/II Study of CLOLAR® (Clofarabine, IND# 73,789) in Combination with Cytarabine in Pediatric Patients with Refractory/Relapsed Leukemia | Pediatric CIRB | Completed | |
| AAML0531 | COG | A Phase III Randomized Trial of Gemtuzumab Ozogamicin (Mylotarg) Combined with Conventional Chemotherapy for De Novo Acute Myeloid Leukemia (AML) in Children; Adolescents; and Young Adults | Pediatric CIRB | Completed | |
| AAML05P1 | COG | Killer Immunoglobulin-like Receptor (KIR) Incompatible Unrelated Donor Hematopoietic Stem Cell Transplantation (SCT) for AML with Monosomy 7; -5/5q-; High FLT3-ITD AR; or Refractory and Relapsed Acute Myelogenous Leukemia (AML) in Children: A Children's Oncology Group (COG) Study (A Groupwide Pilot Study) | Pediatric CIRB | Completed | |
| AAML0631 | COG | Risk Adapted Treatment of Newly Diagnosed Childhood Acute Promyelocytic Leukemia (APL) Using Arsenic Trioxide (Trisenox IND# 103, 331) during Consolidation: A Phase III Study Limited to COG institutions in the United States & Canada | Pediatric CIRB | Completed | |
| AAML06P1 | COG | A Pilot Study of Lestaurtinib (CEP-701) in Combination with Chemotherapy in Young Patients with Relapsed or Refractory FLT3-mutant Acute Myeloid Leukemia | Pediatric CIRB | Completed | |
| AAML07P1 | COG | A Phase II Pilot Study of Bortezomib (PS-341; Velcade; IND# 58;443) Combined with Reinduction Chemotherapy in Children and Young Adults with Recurrent; Refractory or Secondary Acute Myeloid Leukemia | Pediatric CIRB | Completed | |
| AAML08B1 | COG | Biology Study of Transient Myeloproliferative Disorder (TMD) in Children with Down Syndrome (DS) | Pediatric CIRB | Available to Open |