Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number Sort descending | Lead Group | Study Title | CIRB | Study Status | |
|---|---|---|---|---|---|
| EA2205 | ECOG-ACRIN | A Randomized Phase II Trial Evaluating Chemotherapy vs Chemotherapy plus Bevacizumab and Atezolizumab in Advanced Combined Hepatocellular Carcinoma-Cholangiocarcinoma | Adult CIRB - Late Phase Emphasis | Available to Open | |
| EA2212 | ECOG-ACRIN | A Randomized Phase II Study of Perioperative Atezolizumab +/- Chemotherapy in Resectable MSI-H/dMMR Gastric and Gastroesophageal Junction (GEJ) Cancer | Adult CIRB - Early Phase Emphasis | Available to Open | |
| EA2222 | ECOG-ACRIN | A Randomized Phase III Study of Systemic Therapy with or without Hepatic Arterial Infusion for Unresectable Colorectal Liver Metastases: The PUMP Trial | Adult CIRB - Late Phase Emphasis | Available to Open | |
| EA3132 | ECOG-ACRIN | Phase II Randomized Trial of Radiotherapy with or without Cisplatin for Surgically Resected Squamous Cell Carcinoma of the Head and Neck (SCCHN) with TP53 Sequencing | Adult CIRB - Late Phase Emphasis | Available to Open | |
| EA3161 | ECOG-ACRIN | A Phase II/III Randomized Study of Maintenance Nivolumab versus Observation in Patients with Locally Advanced, Intermediate Risk HPV Positive OPSCC | Adult CIRB - Late Phase Emphasis | Available to Open | |
| EA3163 | ECOG-ACRIN | Phase II Randomized Trial of Neo-Adjuvant Chemotherapy followed by Surgery and Post-Operative Radiation versus Surgery and Post-Operative Radiation for Organ Preservation of T3 and T4a Nasal and Paranasal Sinus Squamous Cell Carcinoma (NPNSCC) | Adult CIRB - Late Phase Emphasis | Available to Open | |
| EA3191 | ECOG-ACRIN | A Phase II Randomized Trial of Adjuvant Therapy with Pembrolizumab after Resection of Recurrent/Second Primary Head and Neck Squamous Cell Carcinoma with High Risk Features | Adult CIRB - Late Phase Emphasis | Available to Open | |
| EA3202 | ECOG-ACRIN | A Phase II/III Trial of Chemotherapy + Cetuximab vs Chemotherapy + Bevacizumab vs Atezolizumab + Bevacizumab Following Progression on Immune Checkpoint Inhibition in Recurrent/Metastatic Head and Neck Cancers | Adult CIRB - Late Phase Emphasis | Available to Open | |
| EA3211 | ECOG-ACRIN | Phase III Randomized Trial of Immunotherapy with or without Consolidative Radiotherapy for Oligometastatic Head and Neck Squamous Cell Carcinoma | Adult CIRB - Late Phase Emphasis | Available to Open | |
| EA3231 | ECOG-ACRIN | A Randomized Phase III Study of BRAF-Targeted Therapy vs Cabozantinib in RAI-Refractory Differentiated Thyroid Cancer with BRAF V600Em | Adult CIRB - Late Phase Emphasis | Available to Open |