CIRB Studies

Below is the current list of studies covered by the CIRB. Participants should refer to ClinicalTrials.gov for general information about clinical trials. Institutions should refer to the Clinical Trials Support Unit (CTSU) website  for enrollment requirements and accrual status information. 

Study documents approved after July 1, 2013 are available to participating institutions for covered studies on the CTSU website. To request documents approved before July 1, 2013, participating institutions can contact the CIRB Helpdesk.

Review CIRB
Study Number Network Study Title CIRB
AOST1521 COG A Phase 2 Study of GPNMB-targeted Antibody-Drug Conjugate; CDX-011 (Glembatumumab Vedotin; CR011-vcMMAE; IND# 128248; NSC# 763737); in Recurrent or Refractory Osteosarcoma Pediatric CIRB
AOST2031 COG A Phase 3 Randomized Controlled Trial Comparing Open vs Thoracoscopic Management of Pulmonary Metastases in Patients with Osteosarcoma Pediatric CIRB
AOST2032 COG A Feasibility and Randomized Phase 2/3 Study of the VEFGR2/MET Inhibitor Cabozantinib in Combination with Cytotoxic Chemotherapy for Newly Diagnosed Osteosarcoma Pediatric CIRB
APAL2020SC COG Pediatric Acute Leukemia (PedAL) Screening Trial – Developing New Therapies for Relapsed Leukemias Pediatric CIRB
APEC14B1 COG The Project: Everychild Protocol: A Registry; Eligibility Screening; Biology and Outcome Study Pediatric CIRB
APEC1621-MASTER COG NCI-COG Pediatric MATCH (Molecular Analysis for Therapy Choice) Study Pediatric CIRB
ARAR0331 COG Treatment of Childhood Nasopharyngeal Carcinoma with Neoadjuvant Chemotherapy and Concomitant Chemoradiotherapy: A Groupwide Phase III Study Pediatric CIRB
ARAR0332 COG Treatment of Adrenocortical Tumors with Surgery plus Lymph Node Dissection and Multiagent Chemotherapy: A Groupwide Phase III Study Pediatric CIRB
ARAR2221 COG Phase 2 Study Using Chemoimmunotherapy with Gemcitabine, Cisplatin and Nivolumab in Newly Diagnosed Nasopharyngeal Carcinoma (NPC) Pediatric CIRB
ARAR2331 COG Prospective Treatment of Types I, II and III Pleuropulmonary Blastoma (PPB) Pediatric CIRB