CIRB Studies

Below is the current list of studies covered by the CIRB. Participants should refer to ClinicalTrials.gov for general information about clinical trials. Institutions should refer to the Clinical Trials Support Unit (CTSU) website  for enrollment requirements and accrual status information. 

Study documents approved after July 1, 2013 are available to participating institutions for covered studies on the CTSU website. To request documents approved before July 1, 2013, participating institutions can contact the CIRB Helpdesk.

Review CIRB
Study Number Network Study Title CIRB
AEWS07P1 COG A Pilot Study of Chemotherapy Intensification by Adding Vincristine; Topotecan; and Cyclophosphamide to Standard Chemotherapy Agents with an Interval Compression Schedule in Newly Diagnosed Patients with Localized Ewing Sarcoma Family of Tumors Pediatric CIRB
AEWS1031 COG A Phase III Randomized Trial of Adding Vincristine-topotecan-cyclophosphamide to Standard Chemotherapy in Initial Treatment of Non-metastatic Ewing Sarcoma: A Groupwide Phase III Study Pediatric CIRB
AEWS1221 COG Randomized Phase 3 Trial Evaluating the Addition of the IGF-1R Monoclonal Antibody Ganitumab (AMG 479; NSC# 750008; IND# 120449) to Multiagent Chemotherapy for Patients with Newly Diagnosed Metastatic Ewing Sarcoma Pediatric CIRB
AGCT0521 COG Treatment of Recurrent or Resistant Pediatric Malignant Germ Cell Tumors with Paclitaxel; Ifosfamide and Carboplatin: A Groupwide Phase II Study Pediatric CIRB
AGCT1531 COG A Phase 3 Study of Active Surveillance for Low risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients with Germ Cell Tumors Pediatric CIRB
AGCT1532 COG Phase 3 Accelerated BEP Trial: A randomized phase 3 trial of accelerated versus standard BEP chemotherapy for patients with intermediate and poor-risk metastatic germ cell tumors Pediatric CIRB
AHEP0731 COG Treatment of Children with All Stages of Hepatoblastoma with Temsirolimus (IND#122782; NSC#683864) Added to High Risk Stratum Treatment: A Groupwide Phase III Study Pediatric CIRB
AHEP1531 COG Pediatric Hepatic Malignancy International Therapeutic Trial (PHITT) Pediatric CIRB
AHOD03P1 COG Treatment of Children with Newly-Diagnosed Low Stage Lymphocyte Predominant Hodgkin Disease (LPHD): A Groupwide Pilot Study Pediatric CIRB
AHOD0431 COG A Phase III Study for the Treatment of Children and Adolescents With Newly Diagnosed Low Risk Hodgkin Disease Pediatric CIRB