Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number Sort descending | Lead Group | Study Title | CIRB | Study Status | |
|---|---|---|---|---|---|
| ADVL1712 | COG | A Feasibility Trial of MLN4924 (Pevonedistat, TAK 924, IND#142772) Given in Combination with Azacitidine, Fludarabine, and Cytarabine, in Children, Adolescents, and Young Adults with Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome | Pediatric CIRB | Available to Open | |
| ADVL1823 | COG | Larotrectinib (LOXO-101, NSC# 788607, IND# 141824) for Previously Untreated TRK Fusion Pediatric Solid Tumors and TRK Fusion Relapsed Pediatric Acute Leukemias | Pediatric CIRB | Available to Open | |
| ADVL18P1 | COG | An Open-Label Feasibility Study to Assess the Safety and Pharmacokinetics of Enasidenib in Pediatric Patients with Relapsed/Refractory Acute Myeloid Leukemia (R/R-AML) with an Isocitrate Dehydrogenase-2 (IDH2) Mutation | Pediatric CIRB | Available to Open | |
| AEPI05N1 | COG | Carcinogen Metabolism; DNA Repair; Parental Exposures and Retinoblastoma: A Groupwide Non-Therapeutic Study | Pediatric CIRB | Completed | |
| AEPI07N1 | COG | Genetic Susceptibility Factors in the Etiology of Neuroblastoma also known as Neuroblastoma Epidemiology in North America (NENA): A Groupwide Non-Therapeutic Study | Pediatric CIRB | Completed | |
| AEWS0521 | COG | A Randomized Phase II Study of Bevacizumab (NSC 704865; BB-IND# 7921) Combined with Vincristine; Topotecan and Cyclophosphamide in Patients with First Recurrent Ewing Sarcoma | Pediatric CIRB | Completed | |
| AEWS0621 | COG | Phase II Trial of Intermediate-Dose Cytarabine to Modulate EWS/FLI for Children and Young Adults with Recurrent or Refractory Ewing Sarcoma | Pediatric CIRB | Completed | |
| AEWS07B1 | COG | A COG Study for Collecting and Banking Ewing Sarcoma Specimens | Pediatric CIRB | Available to Open | |
| AEWS07P1 | COG | A Pilot Study of Chemotherapy Intensification by Adding Vincristine; Topotecan; and Cyclophosphamide to Standard Chemotherapy Agents with an Interval Compression Schedule in Newly Diagnosed Patients with Localized Ewing Sarcoma Family of Tumors | Pediatric CIRB | Completed | |
| AEWS1031 | COG | A Phase III Randomized Trial of Adding Vincristine-topotecan-cyclophosphamide to Standard Chemotherapy in Initial Treatment of Non-metastatic Ewing Sarcoma: A Groupwide Phase III Study | Pediatric CIRB | Available to Open |