CIRB Studies

Below is the current list of studies covered by the CIRB. Participants should refer to ClinicalTrials.gov for general information about clinical trials. Institutions should refer to the Clinical Trials Support Unit (CTSU) website  for enrollment requirements and accrual status information. 

Study documents approved after July 1, 2013 are available to participating institutions for covered studies on the CTSU website. To request documents approved before July 1, 2013, participating institutions can contact the CIRB Helpdesk.

Review CIRB
Study Number Network Study Title CIRB
A091802 Alliance Phase II Randomized Trial of Avelumab Plus Cetuximab versus Avelumab Alone in Advanced Cutaneous Squamous Cell Carcinoma of the Skin (cSCC) Adult CIRB - Late Phase Emphasis
A091902 Alliance A Multicenter Phase II Trial of Paclitaxel with and without Nivolumab in Taxane Naive, and Nivolumab and Cabozantinib in Taxane Pretreated Subjects with Angiosarcoma Adult CIRB - Late Phase Emphasis
A091903 Alliance A Randomized Phase II Trial of Adjuvant Nivolumab with or Without Cabozantinib in Patients with Resected Mucosal Melanoma Adult CIRB - Late Phase Emphasis
A092001 Alliance Phase 2 Randomized Trial of Neoadjuvant or Palliative Chemotherapy with or Without Immunotherapy for Peritoneal Mesothelioma Adult CIRB - Late Phase Emphasis
A092104 Alliance A Randomized Phase 2/3 Study of Olaparib plus Temozolomide versus Investigator's Choice for the Treatment of Patients with Advanced Uterine Leiomyosarcoma after Progression on Prior Chemotherapy Adult CIRB - Late Phase Emphasis
A092105 Alliance Randomized Phase 2 Study of Nivolumab and Ipilimumab with or without Cabozantinib in Patients with Advanced Nasopharyngeal Carcinoma that have Progressed after Platinum Treatment and Immunotherapy Adult CIRB - Late Phase Emphasis
A092107 Alliance A Randomized Phase 2 Trial with a Safety Lead-In to Evaluate Palbociclib versus Palbociclib and Cemiplimab for the Treatment of Advanced Dedifferentiated Liposarcoma Adult CIRB - Late Phase Emphasis
A092205 Alliance Randomized Phase III Trial of Pembrolizumab vs. Pembrolizumab/Cetuximab in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma with Platinum Refractory Disease Adult CIRB - Late Phase Emphasis
A151216 Alliance Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trial (ALCHEMIST) Adult CIRB - Late Phase Emphasis
A151804 Alliance Establishment of a National Biorepository to Advance Studies of Immune-Related Adverse Events Adult CIRB - Late Phase Emphasis