Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number Sort descending | Lead Group | Study Title | CIRB | Study Status | |
|---|---|---|---|---|---|
| 9948 | ETCTN | Phase 1 Dose Escalation and Expansion Cohort of Carboplatin and Gemcitabine with or without M6620 (VX-970) in First or Second Recurrence Platinum-Sensitive Epithelial Ovarian, Peritoneal, and Fallopian Tube Cancer | Adult CIRB - Early Phase Emphasis | Available to Open | |
| 9950 | ETCTN | A Phase I Study of M6620 (VX-970) in Combination with Cisplatin and XRT in Patients with Locally Advanced Head and Neck Squamous Cell Carcinoma (HNSCC; SDC 10060121) | Adult CIRB - Early Phase Emphasis | Available to Open | |
| 9952 | ETCTN | Phase 1 Trial to Determine the Recommended Phase 2 Dose (RP2D) of M6620 (VX‐970) When Combined with Whole Brain Radiotherapy (WBRT) in Patients with Brain Metastases from Lung Cancer | Adult CIRB - Early Phase Emphasis | Completed | |
| 9974 | ETCTN | A phase II study of olaparib plus cediranib in combination with standard therapy for small cell lung cancer | Adult CIRB - Early Phase Emphasis | Completed | |
| 9979 | ETCTN | Phase 1 and Pharmacology Study of Oral 5-iodo-2-pyrimidinone-2-deoxyribose (IPdR) as a Prodrug for IUdR-Mediated Tumor Radiosensitization in Brain Metastases | Adult CIRB - Early Phase Emphasis | Available to Open | |
| 9984 | ETCTN | A Randomized Phase 2 Study of cediranib in Combination with olaparib versus olaparib alone in men with metastatic castration resistant prostate cancer | Adult CIRB - Early Phase Emphasis | Available to Open | |
| A011106 | Alliance | ALTernate approaches for clinical stage II or III Estrogen Receptor positive breast cancer NeoAdjuvant TrEatment (ALTERNATE) in postmenopausal women: A Phase III Study | Adult CIRB - Late Phase Emphasis | Available to Open | |
| A011202 | Alliance | A Randomized Phase III Trial Comparing Axillary Lymph Node Dissection to Axillary Radiation in Breast Cancer Patients (cT1-3 N1) Who Have Positive Sentinel Lymph Node Disease After Neoadjuvant Chemotherapy | Adult CIRB - Late Phase Emphasis | Available to Open | |
| A011203 | Alliance | A Randomized Phase II Trial of Tamoxifen Versus Z-Endoxifen HCL in Postmenopausal Women with Metastatic; Estrogen Receptor Positive; HER2 Negative Breast Cancer | Adult CIRB - Early Phase Emphasis | Available to Open | |
| A011401 | Alliance | Randomized Phase III Trial Evaluating the Role of Weight Loss in Adjuvant Treatment of Overweight and Obese Women with Early Breast Cancer | Adult CIRB - Late Phase Emphasis | Available to Open |