CIRB Studies

Below is the current list of studies covered by the CIRB. Participants should refer to ClinicalTrials.gov for general information about clinical trials. Institutions should refer to the Clinical Trials Support Unit (CTSU) website  for enrollment requirements and accrual status information. 

Study documents approved after July 1, 2013 are available to participating institutions for covered studies on the CTSU website. To request documents approved before July 1, 2013, participating institutions can contact the CIRB Helpdesk.

Review CIRB
Study Number Network Study Title CIRB
PEPN2415 PEP-CTN A Phase I study to assess the safety, tolerability, pharmacokinetics, and preliminary efficacy of AZD1390 (NSC# 852149, IND# 172675) when combined with focal radiation in pediatric patients with High Grade Glioma Pediatric CIRB
RTOG-0126 RTOG A Phase III Randomized Study of High Dose 3D-CRT/IMRT versus Standard Dose 3D-CRT/IMRT in Patients Treated for Localized Prostate Cancer Adult CIRB - Late Phase Emphasis
RTOG-0129 RTOG A Phase III Trial of Concurrent Radiation and Chemotherapy (Followed by Surgery for Residual Primary/N2-3 Nodal Disease) for Advanced Head and Neck Carcinomas Adult CIRB - Late Phase Emphasis
RTOG-0214 RTOG A Phase III Comparison of Prophylactic Cranial Irradiation Versus Observation in Patients With Locally Advanced Non-Small Cell Lung Cancer Adult CIRB - Late Phase Emphasis
RTOG-0232 RTOG A Phase III Study Comparing Combined External Beam Radiation and Transperineal Interstitial Permanent Brachytherapy with Brachytherapy Alone for Selected Patients with Intermediate Risk Prostatic Carcinoma Adult CIRB - Late Phase Emphasis
RTOG-0320 RTOG A Phase III Trial Comparing Whole Brain Radiation and Stereotactic Radiosurgery Alone Versus with Temozolomide or Erlotinib in Patients with Non-Small Cell Lung Cancer and 1-3 Brain Metastases Adult CIRB - Late Phase Emphasis
RTOG-0412-SWOG-S0332 RTOG Phase III Randomized Trial of Preoperative Chemotherapy Versus Preoperative Concurrent Chemotherapy and Thoracic Radiotherapy Followed by Surgical Resection and Consolidation Chemotherapy in Favorable Prognosis Patients With Stage IIIA (N2) Non-Small Cell Lung Cancer Adult CIRB - Late Phase Emphasis
RTOG-0415 RTOG A Phase III Randomized Study of Hypofractionated 3D-CRT/IMRT versus Conventionally Fractionated 3D-CRT/IMRT in Patients with Favorable-Risk Prostate Cancer Adult CIRB - Late Phase Emphasis
RTOG-0421 RTOG A Phase III Trial for Locally Recurrent; Previously Irradiated Head and Neck Cancer: Concurrent Re-Irradiation and Chemotherapy Versus Chemotherapy Alone. Adult CIRB - Late Phase Emphasis
RTOG-0436 RTOG A Phase III Trial Evaluating the Addition of Cetuximab to Paclitaxel; Cisplatin; and Radiation for Patients with Esophageal Cancer who are Treated without Surgery Adult CIRB - Late Phase Emphasis