CIRB Studies

Below is the current list of studies covered by the CIRB. Participants should refer to ClinicalTrials.gov for general information about clinical trials. Institutions should refer to the Clinical Trials Support Unit (CTSU) website  for enrollment requirements and accrual status information. 

Study documents approved after July 1, 2013 are available to participating institutions for covered studies on the CTSU website. To request documents approved before July 1, 2013, participating institutions can contact the CIRB Helpdesk.

Review CIRB
Study Number Network Study Title CIRB
NRG-GI005 NRG Phase II/III Study of Circulating tumOr DNA as a Predictive BiomaRker in Adjuvant Chemotherapy in Patients with Stage IIA Colon Cancer (COBRA) Adult CIRB - Late Phase Emphasis
NRG-GI006 NRG Phase III Randomized Trial of Proton Beam Therapy (PBT) versus Intensity Modulated Photon Radiotherapy (IMRT) for the Treatment of Esophageal Cancer Adult CIRB - Late Phase Emphasis
NRG-GI007 NRG Phase I Trial with Expansion Cohort of OBP-301 (Telomelysin™) and Definitive Chemoradiation for Patients with Locally Advanced Esophageal and Gastroesophageal Adenocarcinoma Who Are Not Candidates for Surgery Adult CIRB - Late Phase Emphasis
NRG-GI008 NRG Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease (CIRCULATE-US) Adult CIRB - Late Phase Emphasis
NRG-GI011 NRG A Phase III Randomized Trial of Dose Escalated Radiation in Locally Advanced Pancreas Cancer (LAPC) Patients (LAP100) Adult CIRB - Late Phase Emphasis
NRG-GI012 NRG Phase III Randomized Trial of IO-Based Systemic Treatment +/- Liver SBRT in Hepatocellular Cancer with Macrovascular Invasion (HELIO-RT) Adult CIRB - Late Phase Emphasis
NRG-GU001 NRG Randomized Phase II Trial of Postoperative Adjuvant IMRT Following Cystectomy for pT3/pT4 Urothelial Bladder Cancer Adult CIRB - Late Phase Emphasis
NRG-GU002 NRG Phase II-III Trial of Adjuvant Radiotherapy and Androgen Deprivation following Radical Prostatectomy with or without Adjuvant Docetaxel Adult CIRB - Late Phase Emphasis
NRG-GU003 NRG A Randomized Phase III Trial of Hypofractionated Post-Prostatectomy Radiation Therapy (HYPORT) versus Conventional Post-Prostatectomy Radiation Therapy (COPORT) Adult CIRB - Late Phase Emphasis
NRG-GU005 NRG Phase III IGRT and SBRT vs IGRT and Hypofractionated IMRT for Localized Intermediate Risk Prostate Cancer Adult CIRB - Late Phase Emphasis