CIRB Studies

Below is the current list of studies covered by the CIRB. Participants should refer to ClinicalTrials.gov for general information about clinical trials. Institutions should refer to the Clinical Trials Support Unit (CTSU) website  for enrollment requirements and accrual status information. 

Study documents approved after July 1, 2013 are available to participating institutions for covered studies on the CTSU website. To request documents approved before July 1, 2013, participating institutions can contact the CIRB Helpdesk.

Review CIRB
Study Number Network Study Title CIRB
NRG-CC015 NRG Harnessing E-Mindfulness Approaches for Living-After Breast Cancer---HEAL-ABC Cancer Prevention and Control CIRB
NRG-DT001 NRG A Phase Ib Trial of Neoadjuvant AMG 232 (KRT-232) Concurrent with Preoperative Radiotherapy in Wild-Type P53 Soft Tissue Sarcoma (STS) Adult CIRB - Early Phase Emphasis
NRG-GI001 NRG Randomized Phase III Study of Focal Radiation Therapy for Unresectable; Localized Intrahepatic Cholangiocarcinoma Adult CIRB - Late Phase Emphasis
NRG-GI002 NRG A Phase II Clinical Trial Platform of Sensitization Utilizing Total Neoadjuvant Therapy (TNT) in Rectal Cancer Adult CIRB - Late Phase Emphasis
NRG-GI003 NRG Phase III Randomized Trial of Protons versus Photons for Hepatocellular Carcinoma Adult CIRB - Late Phase Emphasis
NRG-GI004 NRG Colorectal Cancer Metastatic dMMR Immuno-Therapy (COMMIT) Study: A Randomized Phase III Study of mFOLFOX6/Bevacizumab Combination Chemotherapy with or without Atezolizumab or Atezolizumab Monotherapy in the First-Line Treatment of Patients with Deficient DNA Mismatch Repair (dMMR) Metastatic Colorectal Cancer Adult CIRB - Late Phase Emphasis
NRG-GI005 NRG Phase II/III Study of Circulating tumOr DNA as a Predictive BiomaRker in Adjuvant Chemotherapy in Patients with Stage IIA Colon Cancer (COBRA) Adult CIRB - Late Phase Emphasis
NRG-GI006 NRG Phase III Randomized Trial of Proton Beam Therapy (PBT) versus Intensity Modulated Photon Radiotherapy (IMRT) for the Treatment of Esophageal Cancer Adult CIRB - Late Phase Emphasis
NRG-GI007 NRG Phase I Trial with Expansion Cohort of OBP-301 (Telomelysin™) and Definitive Chemoradiation for Patients with Locally Advanced Esophageal and Gastroesophageal Adenocarcinoma Who Are Not Candidates for Surgery Adult CIRB - Late Phase Emphasis
NRG-GI008 NRG Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease (CIRCULATE-US) Adult CIRB - Late Phase Emphasis