NRG-HN003
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NRG
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A Phase I and Expansion Cohort Study of Adjuvant Cisplatin; Intensity-Modulated Radiotherapy; and MK-3475 (Pembrolizumab) in High-Risk Head and Neck Squamous Cell Carcinoma (HNSCC)
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Adult CIRB - Early Phase Emphasis
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Completed
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NRG-HN004
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NRG
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Randomized Phase II/III Trial of Radiotherapy with Concurrent MEDI4736 (Durvalumab) vs. Radiotherapy with Concurrent Cetuximab in Patients with Locoregionally Advanced Head and Neck Cancer with a Contraindication to Cisplatin
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Adult CIRB - Late Phase Emphasis
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Available to Open
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NRG-HN005
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NRG
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A Randomized Phase II/III Trial of De-intensified Radiation Therapy for Patients with Early-Stage, p16-Positive, Non-Smoking Associated Oropharyngeal Cancer
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Adult CIRB - Late Phase Emphasis
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Available to Open
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NRG-HN006
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NRG
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Randomized Phase II/III Trial of Sentinel Lymph Node Biopsy versus Elective Neck Dissection for Early-Stage Oral Cavity Cancer
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Adult CIRB - Late Phase Emphasis
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Available to Open
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NRG-HN007
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NRG
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An Open-Label, Phase III Study of Platinum-Gemcitabine with or without Nivolumab in the First-Line Treatment of Recurrent or Metastatic Nasopharyngeal Carcinoma
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Adult CIRB - Late Phase Emphasis
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Completed
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NRG-HN008
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NRG
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Phase I Trial with Expansion Cohort of DNA-PK Inhibition and IMRT in Cisplatin-Ineligible Patients with Stage 3-4 Local-Regionally Advanced Head and Neck Squamous Cell Carcinoma (HNSCC)
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Adult CIRB - Early Phase Emphasis
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Available to Open
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NRG-HN009
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NRG
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Randomized Phase II/III Trial of Radiation with High-Dose Cisplatin (100 mg/m2) Every Three Weeks Versus Radiation with Low-Dose Weekly Cisplatin (40 mg/m2) for Patients with Locoregionally Advanced Squamous Cell Carcinoma of the Head and Neck (SCCHN)
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Adult CIRB - Late Phase Emphasis
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Available to Open
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NRG-HN010
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NRG
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A Controlled, Randomized Phase II Trial of Docetaxel Plus Trastuzumab Versus Ado-Trastuzumab Emtansine for Recurrent, Metastatic, or Treatment-Naïve, Unresectable HER2-Positive Salivary Gland Cancer
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Adult CIRB - Late Phase Emphasis
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Available to Open
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NRG-HN011
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NRG
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A Randomized Phase II Study of Nivolumab Versus Nivolumab and BMS-986016 (Relatlimab) as Maintenance Treatment After First-Line Treatment with Platinum-Gemcitabine-Nivolumab for Patients with Epstein-Barr Virus-Associated Recurrent/Metastatic Nasopharyngeal Carcinoma (REMAIN)
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Adult CIRB - Late Phase Emphasis
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Available to Open
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NRG-LU001
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NRG
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Randomized Phase II Trial of Concurrent Chemoradiotherapy +/- Metformin HCL in Locally Advanced NSCLC
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Adult CIRB - Late Phase Emphasis
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Available to Open
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