Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number Sort descending | Lead Group | Study Title | CIRB | Study Status | |
|---|---|---|---|---|---|
| 10296 | ETCTN | Phase Ib/II trial of copanlisib in combination with trastuzumab and pertuzumab after induction treatment of HER2 positive (HER2+) metastatic breast cancer (MBC) with PIK3CA mutation or PTEN mutation | Adult CIRB - Early Phase Emphasis | Completed | |
| 10299 | ETCTN | A Phase I Study to Investigate the Safety of the Ubiquitin Activating Enzyme Inhibitor TAK-243 in Adult Solid Tumor and Lymphoma Patients | Adult CIRB - Early Phase Emphasis | Available to Open | |
| 10300 | ETCTN |
BLockade of PD-1 Added to Standard Therapy to target Measurable Residual Disease in Acute Myeloid Leukemia 1 (BLAST MRD AML-1): A Randomized Phase 2 Study of the Anti-PD-1 Antibody Pembrolizumab in Combination with Conventional Intensive Chemotherapy as Frontline Therapy in Patients with Acute Myeloid Leukemia |
Adult CIRB - Early Phase Emphasis | Available to Open | |
| 10301 | ETCTN | A Phase I and Randomized Phase II Trial of Radium-223 dichloride, M3814, & Avelumab in Advanced Metastatic Castrate-Resistant Prostate Cancer (mCRPC) | Adult CIRB - Early Phase Emphasis | Available to Open | |
| 10302 | ETCTN | Phase II Trial of Radium-223 Dichloride in Combination with Paclitaxel in Patients with Bone Metastatic Breast Cancer | Adult CIRB - Early Phase Emphasis | Available to Open | |
| 10313 | ETCTN | A phase IB and randomized open-label phase II study of M6620 in combination with carboplatin/gemcitabine/avelumab in patients with chemotherapy-naïve advanced non-small cell lung cancer of squamous cell histology | Adult CIRB - Early Phase Emphasis | Available to Open | |
| 10315 | ETCTN | A Phase 2 Study of XL184 (Cabozantinib) in Combination with Nivolumab and Ipilimumab for the Treatment of Poorly Differentiated Neuroendocrine Carcinomas | Adult CIRB - Early Phase Emphasis | Available to Open | |
| 10317 | ETCTN | A Pilot Study of Nivolumab in Combination with Decitabine and Venetoclax in TP53-mutated Acute Myeloid Leukemia | Adult CIRB - Early Phase Emphasis | Completed | |
| 10324 | ETCTN | A Phase I/Ib Dose Escalation Study of Pegylated Liposomal Doxorubicin (PLD) With M3814 in Platinum-Resistant or Ineligible Ovarian and Related Cancers with Planned Expansions in High Grade Serous (HGSOC) and Low Grade Serous Ovarian Cancer (LGSOC) | Adult CIRB - Early Phase Emphasis | Available to Open | |
| 10327 | ETCTN | A Phase 1 Trial of MLN0128 (sapanisertib) and CB-839 HCl (telaglenastat) in Advanced NSCLC Patients | Adult CIRB - Early Phase Emphasis | Available to Open |