CIRB Studies

Below is the current list of studies covered by the CIRB. Participants should refer to ClinicalTrials.gov for general information about clinical trials. Institutions should refer to the Clinical Trials Support Unit (CTSU) website  for enrollment requirements and accrual status information. 

Study documents approved after July 1, 2013 are available to participating institutions for covered studies on the CTSU website. To request documents approved before July 1, 2013, participating institutions can contact the CIRB Helpdesk.

Review CIRB
Study Number Network Study Title CIRB
EA8141 ECOG-ACRIN A Prospective Phase II Trial of Neoadjuvant Systemic Chemotherapy followed by Extirpative Surgery for Patients with High Grade Upper Tract Urothelial Carcinoma Adult CIRB - Late Phase Emphasis
EA8143 ECOG-ACRIN A Phase 3 RandOmized Study Comparing PERioperative Nivolumab vs. Observation in Patients with Renal Cell Carcinoma Undergoing Nephrectomy (PROSPER RCC) Adult CIRB - Late Phase Emphasis
EA8153 ECOG-ACRIN Cabazitaxel with Abiraterone versus Abiraterone alone Randomized Trial for Extensive Disease following Docetaxel: the CHAARTED2 Trial Adult CIRB - Late Phase Emphasis
EA8171 ECOG-ACRIN Multiparametric MRI (mpMRI) for Preoperative Staging and Treatment Planning for Newly-Diagnosed Prostate Cancer Adult CIRB - Late Phase Emphasis
EA8183 ECOG-ACRIN A Phase III Double Blinded Study of Early Intervention after RADICAl ProstaTEctomy with Androgen Deprivation Therapy with Darolutamide vs. Placebo in Men at Highest Risk of Prostate Cancer Metastasis by Genomic Stratification (ERADICATE) Adult CIRB - Late Phase Emphasis
EA8184 ECOG-ACRIN A Phase II Randomized Double Blinded Study of Green Tea Catechins (GTC) vs. Placebo in Men on Active Surveillance for Prostate Cancer: Modulation of Biological and Clinical Intermediate Biomarkers Cancer Prevention and Control CIRB
EA8185 ECOG-ACRIN Phase 2 Study of Bladder-SparIng ChemoradiatioN with MEDI4736 (Durvalumab) in clinical Stage 3, Node PosItive bladdeR cancEr (INSPIRE) Adult CIRB - Late Phase Emphasis
EA8191 ECOG-ACRIN Phase III Study of PET-Directed Local or Systemic Therapy Intensification in Prostate Cancer Patients with Post-Prostatectomy Biochemical Recurrence Adult CIRB - Late Phase Emphasis
EA8192 ECOG-ACRIN A Phase II/III trial of MEDI4736 (Durvalumab) and Chemotherapy for Patients with High Grade Upper Tract Urothelial Cancer Prior to Nephroureterectomy Adult CIRB - Late Phase Emphasis
EA8211 ECOG-ACRIN Phase III Randomized Trial of Stereotactic Ablative Radiotherapy (SAbR) for Oligometastatic Advanced Renal Carcinoma (SOAR) Adult CIRB - Late Phase Emphasis