CIRB Studies

Below is the current list of studies covered by the CIRB. Participants should refer to ClinicalTrials.gov for general information about clinical trials. Institutions should refer to the Clinical Trials Support Unit (CTSU) website  for enrollment requirements and accrual status information. 

Study documents approved after July 1, 2013 are available to participating institutions for covered studies on the CTSU website. To request documents approved before July 1, 2013, participating institutions can contact the CIRB Helpdesk.

Review CIRB
Study Number Network Study Title CIRB
EA6134 ECOG-ACRIN DREAMseq (Doublet, Randomized Evaluation in Advanced Melanoma Sequencing) A Phase III Trial Adult CIRB - Late Phase Emphasis
EA6141 ECOG-ACRIN Randomized Phase II/III Study of Nivolumab plus Ipilimumab plus Sargramostim versus Nivolumab plus Ipilimumab in Patients with Unresectable Stage III or Stage IV Melanoma Adult CIRB - Late Phase Emphasis
EA6174 ECOG-ACRIN STAMP: Surgically Treated Adjuvant Merkel cell Carcinoma with Pembrolizumab, a Phase III Trial Adult CIRB - Late Phase Emphasis
EA6183 ECOG-ACRIN A Phase II Neoadjuvant Study of Encorafenib with Binimetinib in Patients with Resectable Locoregional Metastases from Cutaneous or Unknown Primary Melanoma (Stages III N1B/C/D) Adult CIRB - Late Phase Emphasis
EA6191 ECOG-ACRIN The BAMM2 (BRAF, Autophagy, MEK inhibition in Melanoma) Study: A Randomized Double Blind Phase II Study of Dabrafenib and Trametinib with or without Hydroxychloroquine in Advanced BRAF V600E/K Melanoma Adult CIRB - Late Phase Emphasis
EA6192 ECOG-ACRIN A Phase II Study of Biomarker Driven Early Discontinuation of Anti-PD-1 Therapy in Patients with Advanced Melanoma (PET-Stop) Adult CIRB - Late Phase Emphasis
EA6194 ECOG-ACRIN Phase II Randomized Study of Neoadjuvant Pembrolizumab Alone or in Combination with CMP-001 in Patients with Operable Melanoma: Efficacy and Biomarker Study Adult CIRB - Late Phase Emphasis
EA7211 ECOG-ACRIN A Randomized Phase III Study of Neoadjuvant Chemotherapy followed by Surgery versus Surgery Alone for Patients with High Risk RetroPeritoneal Sarcoma (STRASS 2) Adult CIRB - Late Phase Emphasis
EA7222 ECOG-ACRIN A Randomized Phase III Trial of Doxorubicin + Pembrolizumab Versus Doxorubicin Alone for the Treatment of Undifferentiated Pleomorphic Sarcoma (UPS) and Related Poorly Differentiated Sarcomas Adult CIRB - Late Phase Emphasis
EA8134 ECOG-ACRIN InPACT- International Penile Advanced Cancer Trial (International Rare Cancers Initiative Study) Adult CIRB - Late Phase Emphasis