CIRB Studies

Below is the current list of studies covered by the CIRB. Participants should refer to ClinicalTrials.gov for general information about clinical trials. Institutions should refer to the Clinical Trials Support Unit (CTSU) website  for enrollment requirements and accrual status information. 

Study documents approved after July 1, 2013 are available to participating institutions for covered studies on the CTSU website. To request documents approved before July 1, 2013, participating institutions can contact the CIRB Helpdesk.

Review CIRB
Study Number Sort descending Network Study Title CIRB
ANZGOG-0902-GOG-0274 GOG A Phase III Trial of Adjuvant Chemotherapy Following Chemoradiation as Primary Treatment for Locally Advanced Cervical Cancer Compared to Chemoradiation Alone: THE OUTBACK TRIAL (ANZGOG 0902/GOG-0274/RTOG 1174) Adult CIRB - Late Phase Emphasis
AOST0331 COG A Randomized Trial of the European and American Osteosarcoma Study Group to Optimize Treatment Strategies for Resectable Osteosarcoma Based on Histological Response to Pre-Operative Chemotherapy (IND# 12697): A Phase III Intergroup Study Pediatric CIRB
AOST06B1 COG A Children's Oncology Group Protocol for Collecting and Banking Osteosarcoma Specimens Pediatric CIRB
AOST06P1 COG Feasibility and Dose Discovery Analysis of Zoledronic Acid with Concurrent Chemotherapy in the Treatment of Newly Diagnosed Metastatic Osteosarcoma: A Groupwide Pilot Study Pediatric CIRB
AOST1321 COG Phase II Study of Denosumab (IND #127430; NSC# 744010); a RANK Ligand Antibody; for Recurrent or Refractory Osteosarcoma Pediatric CIRB
AOST1322 COG A Phase II Study of Eribulin (IND# 122686; NSC# 707389) in Recurrent or Refractory Osteosarcoma: An Intergroup NCTN Phase II Study Pediatric CIRB
AOST1421 COG A Phase II Study of Human-Mouse Chimeric Anti-Disialoganglioside Monoclonal Antibody ch14.18 (Dinutuximab; NSC# 764038; IND# 4308) in Combination with Sargramostim (GM-CSF) in Patients with Recurrent Osteosarcoma Pediatric CIRB
AOST1521 COG A Phase 2 Study of GPNMB-targeted Antibody-Drug Conjugate; CDX-011 (Glembatumumab Vedotin; CR011-vcMMAE; IND# 128248; NSC# 763737); in Recurrent or Refractory Osteosarcoma Pediatric CIRB
AOST2031 COG A Phase 3 Randomized Controlled Trial Comparing Open vs Thoracoscopic Management of Pulmonary Metastases in Patients with Osteosarcoma Pediatric CIRB
AOST2032 COG A Feasibility and Randomized Phase 2/3 Study of the VEFGR2/MET Inhibitor Cabozantinib in Combination with Cytotoxic Chemotherapy for Newly Diagnosed Osteosarcoma Pediatric CIRB