Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number Sort descending | Lead Group | Study Title | CIRB | Study Status | |
|---|---|---|---|---|---|
| ACNS1021 | COG | A Phase II Study of Sunitinib (NSC# 736511; IND# 74019) in Recurrent; Refractory or Progressive High Grade Glioma and Ependymoma Tumors in Pediatric and Young Adult Patients | Pediatric CIRB | Completed | |
| ACNS1022 | COG | A Phase II Randomized Trial of Lenalidomide (NSC # 703813; IND # 70116) in Pediatric Patients with Recurrent; Refractory or Progressive Juvenile Pilocytic Astrocytomas and Optic Pathway Gliomas: A Groupwide Phase II Study | Pediatric CIRB | Available to Open | |
| ACNS1123 | COG | Phase 2 Trial of Response-Based Radiation Therapy for Patients with Localized Central Nervous System Germ Cell Tumors (CNS GCT): A Groupwide Phase II Study | Pediatric CIRB | Available to Open | |
| ACNS1221 | COG | A Phase II Study For The Treatment Of Non-Metastatic Nodular Desmoplastic Medulloblastoma In Children Less Than 4 Years Of Age: A Groupwide Phase II Study | Pediatric CIRB | Completed | |
| ACNS1422 | COG | A Phase 2 Study of Reduce Therapy for Newly Diagnosed Average-Risk WNT-Driven Medulloblastoma Patients | Pediatric CIRB | Available to Open | |
| ACNS1721 | COG | A Phase 2 Study of Veliparib (ABT-888, IND # 139199) and Local Irradiation, Followed by Maintenance Veliparib and Temozolomide, in Patients with Newly Diagnosed High-Grade Glioma (HGG) without H3 K27M or BRAFV600E Mutations | Pediatric CIRB | Available to Open | |
| ACNS1723 | COG | A Phase 2 Study of Dabrafenib (NSC# 763760) with Trametinib (NSC# 763093) after Local Irradiation in Newly-Diagnosed BRAFV600-Mutant High-Grade Glioma (HGG) (IND# 145355) | Pediatric CIRB | Available to Open | |
| ACNS1821 | COG | A Phase 1/2 Trial of Selinexor (KPT-330, IND#159140) and Radiation Therapy in Newly-Diagnosed Pediatric Diffuse Intrinsic Pontine Glioma (DIPG) and High-Grade Glioma (HGG) | Pediatric CIRB | Available to Open | |
| ACNS1831 | COG | A Phase 3 Randomized Study of Selumetinib (IND # 77782) versus Carboplatin/Vincristine in Newly Diagnosed or Previously Untreated Neurofibromatosis Type 1 (NF1) Associated Low-Grade Glioma (LGG) | Pediatric CIRB | Available to Open | |
| ACNS1833 | COG | A Phase 3 Randomized Non-Inferiority Study of Carboplatin and Vincristine versus Selumetinib (NSC# 748727, IND# 77782) in Newly Diagnosed or Previously Untreated Low-Grade Glioma (LGG) not associated with BRAFV600E Mutations or Systemic Neurofibromatosis Type 1 (NF1) | Pediatric CIRB | Available to Open |