CIRB Studies

Below is the current list of studies covered by the CIRB. Participants should refer to ClinicalTrials.gov for general information about clinical trials. Institutions should refer to the Clinical Trials Support Unit (CTSU) website  for enrollment requirements and accrual status information. 

Study documents approved after July 1, 2013 are available to participating institutions for covered studies on the CTSU website. To request documents approved before July 1, 2013, participating institutions can contact the CIRB Helpdesk.

Review CIRB
Study Number Network Study Title CIRB
10647 ETCTN Phase I/Ib Study of Eribulin in Combination with ASTX660 (tolinapant) in Metastatic Triple Negative Breast Cancer (TNBC) Adult CIRB - Early Phase Emphasis
10653 ETCTN A Phase I Study of Lintuzumab-Ac225 in Combination with Venetoclax and ASTX-727 in Adults with Newly Diagnosed AML Adult CIRB - Early Phase Emphasis
10655 ETCTN Phase I Clinical Trial of CA-4948 (emavusertib) in Combination with FOLFOX Plus Bevacizumab as Frontline Treatment in Patients with Metastatic Colorectal Cancer Adult CIRB - Early Phase Emphasis
10657 ETCTN Phase I/II Study to Evaluate the Feasibility and Efficacy of Sequential Abemaciclib and Gemcitabine Treatment in Patients with Retinoblastoma (Rb)+ Sarcomas Adult CIRB - Early Phase Emphasis
10664 ETCTN A Phase 1 Study of Combination Tovorafenib (DAY101) and Rituximab Treatment in Relapsed or Refractory Classical Hairy Cell Leukemia and Phase 2 Randomized Study Comparing Tovorafenib (DAY101) and Rituximab with Cladribine and Rituximab for Front-line Treatment of Classical Hairy Cell Leukemia Adult CIRB - Early Phase Emphasis
10667 ETCTN Pilot Study of Pidnarulex Pharmacodynamics in Patients with Advanced Solid Tumors Adult CIRB - Early Phase Emphasis
10670 ETCTN A Phase 1 Study of 5-Fluorouracil in Combination with Abemaciclib in Metastatic, Refractory CRC Adult CIRB - Early Phase Emphasis
10674 ETCTN A Phase I Study Evaluating the Safety of Cirtuvivint as Monotherapy and in Combination with ASTX727 in Patients with Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML) Adult CIRB - Early Phase Emphasis
10675 ETCTN A Randomized Phase 2 Trial of ASTX727 +/- Iadademstat in Accelerated/Blast-Phase Philadelphia Chromosome-Negative Myeloproliferative Neoplasms (MPNs) Adult CIRB - Early Phase Emphasis
10695 ETCTN Phase 1 Study of Lintuzumab-Ac225 Monotherapy for Patients with Hypomethylating Agent-Refractory Myelodysplastic Syndrome Adult CIRB - Early Phase Emphasis