Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number Sort descending | Lead Group | Study Title | CIRB | Study Status | |
|---|---|---|---|---|---|
| 10402 | ETCTN | BAY 1895344 Plus Topoisomerase-1 (Top1) Inhibitors in Patients with Advanced Solid Tumors, Phase I Studies with Expansion Cohorts in Small Cell Lung Carcinoma (SCLC), Poorly Differentiated Neuroendocrine Carcinoma (PD-NEC) and Pancreatic Adenocarcinoma (PDA) | Adult CIRB - Early Phase Emphasis | Available to Open | |
| 10403 | ETCTN | Phase 1 Trial of Gemcitabine Combined with the BAY 1895344 ATR Inhibitor with Expansion Cohorts in Advanced Pancreatic and Ovarian Cancer | Adult CIRB - Early Phase Emphasis | Available to Open | |
| 10404 | ETCTN | A Phase 1 Trial of the ATR Inhibitor BAY 1895344 in Combination with Cisplatin and with Cisplatin Plus Gemcitabine in Advanced Solid Tumors with an Emphasis on Urothelial Carcinoma | Adult CIRB - Early Phase Emphasis | Available to Open | |
| 10405 | ETCTN | Phase I Trial of BAY 1895344 ATR Inhibitor Combined with Stereotactic Body Radiation Therapy and Pembrolizumab for Recurrent Head and Neck Squamous Cell Carcinoma | Adult CIRB - Early Phase Emphasis | Available to Open | |
| 10406 | ETCTN | Phase 1/1b Trial of ATR Inhibitor BAY 1895344 in Combination with FOLFIRI in GI Malignancies with a Focus on Metastatic Colorectal and Gastric/Gastroesophageal Cancers | Adult CIRB - Early Phase Emphasis | Available to Open | |
| 10410 | ETCTN | A Phase 1 Study of IPdR in Combination with Capecitabine and Radiotherapy in Rectal Cancer | Adult CIRB - Early Phase Emphasis | Completed | |
| 10411 | ETCTN | Phase 2 Study of Rogaratinib (BAY 1163877) in the Treatment of Patients with Sarcoma Harboring Alterations in Fibroblast Growth Factor Receptor (FGFR) 1-4 and SDH-deficient Gastrointestinal Stromal Tumor (GIST) | Adult CIRB - Early Phase Emphasis | Available to Open | |
| 10417 | ETCTN | Clinical Evaluation of ASTX727 in Combination with Venetoclax All-Oral Therapy vs. Standard of Care Cytarabine and Anthracycline Induction Chemotherapy for Younger FLT3WT Patients with ELN High-Risk Acute Myeloid Leukemia | Adult CIRB - Early Phase Emphasis | Available to Open | |
| 10422 | ETCTN | A Phase 1/1b Dose Escalation Study of Abemaciclib and Olaparib for Recurrent Platinum-Resistant Ovarian Cancer | Adult CIRB - Early Phase Emphasis | Available to Open | |
| 10433 | ETCTN | Phase I/Ib trial evaluating the safety and efficacy of BET inhibitor, ZEN003694 with PD-1 inhibitor, nivolumab with or without CTLA-4 inhibitor, ipilimumab in solid tumors | Adult CIRB - Early Phase Emphasis | Available to Open |