The CIRB consists of four separate boards — each of which is responsible for specific types of studies.
- Adult CIRB - Early Phase Emphasis
- Adult CIRB - Late Phase Emphasis
- Pediatric CIRB
- Cancer Prevention and Control CIRB
The National Cancer Institute funds an extensive national program of cancer research, including pilot, phase 1, phase 2, and phase 3 clinical trials in adults and children focused on cancer prevention, cancer care and delivery, and treatment. The CIRB is an independent organization that provides reviews of NCI-funded clinical studies.
The CIRB provides review of protocols submitted by these Networks to ensure the safety of all participants in the trial. The current list of supported Networks includes:
- NCI National Clinical Trials Network (NCTN)
- NCI Experimental Therapeutics Clinical Trials Network (ETCTN)
- NCI Community Oncology Research Program (NCORP)
- Phase 0/I/II Cancer Prevention Clinical Trials Program (Consortia) and Cancer Prevention Clinical Trials Network (CP-CTNet)
- Adult Brain Tumor Consortium (ABTC)
- Pediatric Brain Tumor Consortium (PBTC)
- AIDS Malignancy Consortium (AMC)
The CIRB supports more than 1,800 institutions, such as hospitals and universities, conducting clinical studies aimed at preventing and treating cancer. The CIRB provides timely, efficient, and responsive reviews of NCI-funded clinical trials conducted at these institutions. These reviews establish the institution and Principal Investigator's local context.