CIRB Studies
Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number | Lead Group | Study Title | CIRB | Study Status |
|---|---|---|---|---|
| 10300 | ETCTN | BLockade of PD-1 Added to Standard Therapy to target Measurable Residual Disease in Acute Myeloid Leukemia 1 (BLAST MRD AML-1): A Randomized Phase 2 Study of the Anti-PD-1 Antibody Pembrolizumab in Combination with Conventional Intensive Chemotherapy as Frontline Therapy in Patients with Acute Myeloid Leukemia | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10301 | ETCTN | A Phase I and Randomized Phase II Trial of Radium-223 dichloride, M3814, & Avelumab in Advanced Metastatic Castrate-Resistant Prostate Cancer (mCRPC) | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10302 | ETCTN | Phase II Trial of Radium-223 Dichloride in Combination with Paclitaxel in Patients with Bone Metastatic Breast Cancer | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10313 | ETCTN | A phase IB and randomized open-label phase II study of M6620 in combination with carboplatin/gemcitabine/avelumab in patients with chemotherapy-naïve advanced non-small cell lung cancer of squamous cell histology | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10315 | ETCTN | A Phase 2 Study of XL184 (Cabozantinib) in Combination with Nivolumab and Ipilimumab for the Treatment of Poorly Differentiated Neuroendocrine Carcinomas | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10317 | ETCTN | A Pilot Study of Nivolumab in Combination with Decitabine and Venetoclax in TP53-mutated Acute Myeloid Leukemia | Adult CIRB - Early Phase Emphasis | Completed |
| 10324 | ETCTN | A Phase I/Ib Dose Escalation Study of Pegylated Liposomal Doxorubicin (PLD) With M3814 in Platinum-Resistant or Ineligible Ovarian and Related Cancers with Planned Expansions in High Grade Serous (HGSOC) and Low Grade Serous Ovarian Cancer (LGSOC) | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10327 | ETCTN | A Phase 1 Trial of MLN0128 (sapanisertib) and CB-839 HCl (telaglenastat) in Advanced NSCLC Patients | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10329 | ETCTN | Phase I Sequential Trial of Agents Against DNA Repair (STAR) | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10330 | ETCTN | A Phase 2 Study of Belinostat and SGI-110 (Guadecitabine) for the Treatment of Unresectable and Metastatic Conventional Chondrosarcoma | Adult CIRB - Early Phase Emphasis | Available to Open |