CIRB Studies
Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number | Lead Group | Study Title | CIRB | Study Status |
|---|---|---|---|---|
| 10315 | ETCTN | A Phase 2 Study of XL184 (Cabozantinib) in Combination with Nivolumab and Ipilimumab for the Treatment of Poorly Differentiated Neuroendocrine Carcinomas | Adult CIRB - Early Phase Emphasis | Available to Open |
| ACNS1721 | COG | A Phase 2 Study of Veliparib (ABT-888, IND # 139199) and Local Irradiation, Followed by Maintenance Veliparib and Temozolomide, in Patients with Newly Diagnosed High-Grade Glioma (HGG) without H3 K27M or BRAFV600E Mutations | Pediatric CIRB | Available to Open |
| PEPN2121 | PEP-CTN | A Phase 2 Study of Tiragolumab (NSC# 827799) and Atezolizumab (NSC# 783608) in Patients with Relapsed or Refractory SMARCB1 or SMARCA4 Deficient Tumors | Pediatric CIRB | Available to Open |
| 10129 | ETCTN | A Phase 2 Study of the PARP Inhibitor Olaparib (AZD2281) in IDH1 and IDH2 mutant Advanced Solid Tumors | Adult CIRB - Early Phase Emphasis | Available to Open |
| ADVL1521 | COG | A Phase 2 Study of the MEK inhibitor Trametinib (IND #119346, NSC# 763093) in Children with Relapsed or Refractory Juvenile Myelomonocytic Leukemia | Pediatric CIRB | Available to Open |
| 10056 | ETCTN | A Phase 2 Study of Talimogene Laherparepvec (T-VEC) and Radiation in Localized Soft Tissue Sarcoma | Adult CIRB - Early Phase Emphasis | Available to Open |
| AALL2121 | COG | A Phase 2 study of SNDX-5613 in combination with chemotherapy for patients with relapsed or refractory KMT2A-rearranged infant leukemia | Pediatric CIRB | Available to Open |
| 10181 | ETCTN | A Phase 2 Study of Savolitinib in Subjects with MET Amplified Metastatic Colorectal Cancer | Adult CIRB - Early Phase Emphasis | Available to Open |
| ACNS1422 | COG | A Phase 2 Study of Reduce Therapy for Newly Diagnosed Average-Risk WNT-Driven Medulloblastoma Patients | Pediatric CIRB | Available to Open |
| EA2187 | ECOG-ACRIN | A Phase 2 Study of Pevonedistat in Combination with Carboplatin and Paclitaxel in Advanced Intrahepatic Cholangiocarcinoma | Adult CIRB - Late Phase Emphasis | Available to Open |