CIRB Studies
Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number | Lead Group | Study Title | CIRB | Study Status |
|---|---|---|---|---|
| A071701 | Alliance | Genomically-Guided Treatment Trial in Brain Metastases | Adult CIRB - Late Phase Emphasis | Available to Open |
| NRG-GY008 | NRG | A Phase II Evaluation of Copanlisib (BAY 80-6946); (IND #130822); A Selective Inhibitor of PI3KCA; in Patients with Persistent or Recurrent Endometrial Carcinoma Harboring PIK3CA Hotspot Mutations | Adult CIRB - Late Phase Emphasis | Completed |
| RTOG-1112 | RTOG | Randomized Phase III Study of Sorafenib Versus Stereotactic Body Radiation Therapy Followed by Sorafenib in Hepatocellular Carcinoma | Adult CIRB - Late Phase Emphasis | Available to Open |
| S1207 | SWOG | Phase III Randomized; Placebo-Controlled Clinical Trial Evaluating the Use of Adjuvant Endocrine Therapy +/- One Year of Everolimus in Patients with High-Risk Hormone Receptor-Positive and HER2/neu Negative Breast Cancer. e3 Breast Cancer Study - evaluating everolimus with endocrine therapy | Adult CIRB - Late Phase Emphasis | Available to Open |
| E3A06 | ECOG | Randomized Phase III Trial of Lenalidomide versus Observation Alone In Patients with Asymptomatic High-Risk Smoldering Multiple Myeloma | Adult CIRB - Late Phase Emphasis | Available to Open |
| S2302 | SWOG | Pragmatica - Lung: A Prospective Randomized Study of Ramucirumab (LY3009806; NSC 749128) plus Pembrolizumab (MK-3475; NSC 776864) versus Standard of Care (SOC) for Participants Previously Treated with Immunotherapy for Stage IV or Recurrent Non-Small Cell Lung Cancer | Adult CIRB - Late Phase Emphasis | Available to Open |
| CALGB-50303 | CALGB | Phase III Randomized Study of R-CHOP v. Dose-Adjusted EPOCH-R with Molecular Profiling in Untreated De Novo Diffuse Large B-Cell Lymphomas | Adult CIRB - Late Phase Emphasis | Completed |
| S1803 | SWOG | Phase III Study of Daratumumab/rHuPH20 (NSC-810307) + Lenalidomide or Lenalidomide as Post-Autologous Stem Cell Transplant Maintenance Therapy in Patients with Multiple Myeloma (MM) using Minimal Residual Disease to Direct Therapy Duration (DRAMMATIC STUDY) | Adult CIRB - Late Phase Emphasis | Available to Open |
| NSABP-C-08 | NSABP | A Phase III Clinical Trial Comparing Infusional 5-Fluorouracil (5-FU); Leucovorin; and Oxaliplatin (mFOLFOX6) Every Two Weeks with Bevacizumab to the Same Regimen without Bevacizumab for the Treatment of Patients with Resected Stages II and III Carcinoma of the Colon | Adult CIRB - Late Phase Emphasis | Completed |
| CALGB-140503 | CALGB | A Phase III Randomized Trial of Lobectomy versus Sublobar Resection for Small (= 2 Cm) Peripheral Non-Small Cell Lung Cancer | Adult CIRB - Late Phase Emphasis | Available to Open |