CIRB Studies
Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number | Lead Group | Study Title | CIRB | Study Status |
|---|---|---|---|---|
| A011106 | Alliance | ALTernate approaches for clinical stage II or III Estrogen Receptor positive breast cancer NeoAdjuvant TrEatment (ALTERNATE) in postmenopausal women: A Phase III Study | Adult CIRB - Late Phase Emphasis | Available to Open |
| 10186 | ETCTN | A Phase I/II Study of Nivolumab plus or minus Ipilimumab in Combination with Multi-fraction Stereotactic Radiosurgery for Recurrent High-grade Radiation-relapsed Meningioma | Adult CIRB - Early Phase Emphasis | Available to Open |
| NRG-BR004 | NRG | A Randomized, Double-Blind, Phase III Trial of Paclitaxel/Trastuzumab/Pertuzumab with Atezolizumab or Placebo in First-Line HER2-Positive Metastatic Breast Cancer | Adult CIRB - Late Phase Emphasis | Available to Open |
| ABTC-1804 | ABTC | Determining the Dose of Regadenoson Most Likely to Transiently Alter the Integrity of the Blood-Brain Barrier in Patients with Gliomas | Adult CIRB - Late Phase Emphasis | Available to Open |
| S1929 | SWOG | Phase II Randomized Study of Maintenance Atezolizumab Versus Atezolizumab in Combination with Talazoparib in Patients with SLFN11 Positive Extensive Stage Small Cell Lung Cancer (ES-SCLC) | Adult CIRB - Late Phase Emphasis | Available to Open |
| NSABP-B-47 | NSABP | A Randomized Phase III Trial of Adjuvant Therapy Comparing Chemotherapy Alone (Six Cycles of Docetaxel Plus Cyclophosphamide or Four Cycles of Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel) to Chemotherapy Plus Trastuzumab in Women with Node-Positive or High-Risk Node-Negative HER2-Low Invasive Breast Cancer | Adult CIRB - Late Phase Emphasis | Available to Open |
| A211801 | Alliance | BRCA-P: A Randomized, Double-Blind, Placebo-Controlled, Multi-Center, International Phase 3 Study to Determine the Preventive Effect of Denosumab on Breast Cancer in Women Carrying a BRCA1 Germline Mutation | Cancer Prevention and Control CIRB | Available to Open |
| EA2192 | ECOG-ACRIN | APOLLO: A Randomized Phase II Double-Blind Study of Olaparib versus Placebo Following Adjuvant Chemotherapy in Patients with Resected Pancreatic Cancer and a Pathogenic BRCA1, BRCA2 or PALB2 Mutation | Adult CIRB - Late Phase Emphasis | Available to Open |
| S1512 | SWOG | A Phase II and Pilot Trial of PD-1 Blockade with MK-3475 (Pembrolizumab) in Patients with Resectable or Unresectable Desmoplastic Melanoma (DM) | Adult CIRB - Late Phase Emphasis | Available to Open |
| EA1151 | ECOG-ACRIN | Tomosynthesis Mammographic Imaging Screening Trial (TMIST) | Cancer Prevention and Control CIRB | Available to Open |