CIRB Studies
Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number | Lead Group | Study Title | CIRB | Study Status |
|---|---|---|---|---|
| A022102 | Alliance | Randomized Phase III trial of mFOLFIRINOX +/- Nivolumab vs. FOLFOX +/- Nivolumab for First-Line Treatment of Metastatic HER2-Negative Gastroesophageal Adenocarcinoma | Adult CIRB - Late Phase Emphasis | Available to Open |
| A052101 | Alliance | A Randomized Phase 3 Trial of Continuous vs Intermittent Maintenance Therapy with Zanubrutinib as Upfront Treatment in Older Patients with Mantle Cell Lymphoma | Adult CIRB - Late Phase Emphasis | Available to Open |
| A011202 | Alliance | A Randomized Phase III Trial Comparing Axillary Lymph Node Dissection to Axillary Radiation in Breast Cancer Patients (cT1-3 N1) Who Have Positive Sentinel Lymph Node Disease After Neoadjuvant Chemotherapy | Adult CIRB - Late Phase Emphasis | Available to Open |
| A031901 | Alliance | Duration of Immune Checkpoint Therapy in Locally Advanced or Metastatic Urothelial Carcinoma: A Randomized Phase 3 Non-Inferiority Trial | Adult CIRB - Late Phase Emphasis | Available to Open |
| A231901CD | Alliance | Improving Patient-Centered Communication in Breast Cancer: A RCT of a Shared Decision Engagement System (SHARES) | Cancer Prevention and Control CIRB | Available to Open |
| A041501 | Alliance | A Phase III Trial to Evaluate the Efficacy of the Addition of Inotuzumab Ozogamicin (A Conjugated Anti-CD22 Monoclonal Antibody) to Frontline Therapy in Young Adults (Ages 18-39 Years) with Newly Diagnosed Precursor B-Cell ALL | Adult CIRB - Late Phase Emphasis | Available to Open |
| A221505 | Alliance | RT Charm: Phase III Randomized Trial of Hypofractionated Post Mastectomy Radiation with Breast Reconstruction | Cancer Prevention and Control CIRB | Available to Open |
| A171601 | Alliance | A phase II trial assessing the tolerability of palbociclib in combination with letrozole or fulvestrant in patients aged 70 and older with estrogen receptor-positive, HER2-negative metastatic breast cancer | Cancer Prevention and Control CIRB | Available to Open |
| A071401 | Alliance | Phase II Trial of SMO/AKT/NF2/CDK Inhibitors in Progressive Meningiomas with SMO/AKT/NF2/CDK Pathway Mutations | Adult CIRB - Early Phase Emphasis | Available to Open |
| A151804 | Alliance | Establishment of a National Biorepository to Advance Studies of Immune-Related Adverse Events | Adult CIRB - Late Phase Emphasis | Available to Open |