CIRB Studies
Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number | Lead Group | Study Title | CIRB | Study Status |
|---|---|---|---|---|
| NRG-GY025 | NRG | A Randomized Phase II Trial of Nivolumab and Ipilimumab Compared to Nivolumab Monotherapy in Patients with Deficient Mismatch Repair System Recurrent Endometrial Carcinoma | Adult CIRB - Late Phase Emphasis | Available to Open |
| NRG-HN005 | NRG | A Randomized Phase II/III Trial of De-intensified Radiation Therapy for Patients with Early-Stage, p16-Positive, Non-Smoking Associated Oropharyngeal Cancer | Adult CIRB - Late Phase Emphasis | Available to Open |
| NRG-GU003 | NRG | A Randomized Phase III Trial of Hypofractionated Post-Prostatectomy Radiation Therapy (HYPORT) versus Conventional Post-Prostatectomy Radiation Therapy (COPORT) | Adult CIRB - Late Phase Emphasis | Available to Open |
| NRG-LU004 | NRG | Phase I Trial of Accelerated or Conventionally Fractionated Radiotherapy Combined With MEDI4736 (durvalumab) in PD-L1 High Locally Advanced Non-Small Cell Lung Cancer (NSCLC) (ARCHON-1) | Adult CIRB - Early Phase Emphasis | Available to Open |
| NRG-GU013 | NRG | The Phase III "High Five Trial" Five Fraction Radiation for High-Risk Prostate Cancer | Adult CIRB - Late Phase Emphasis | Available to Open |
| NRG-GU012 | NRG | Randomized Phase II Stereotactic Ablative Radiation Therapy (SABR) for Metastatic Unresected Renal Cell Carcinoma (RCC) Receiving Immunotherapy (SAMURAI) | Adult CIRB - Late Phase Emphasis | Available to Open |
| NRG-GY007 | NRG | A Phase I/II Study of Ruxolitinib with Front-Line Neoadjuvant and Post-Surgical Therapy in Patients with Advanced Epithelial Ovarian; Fallopian Tube; or Primary Peritoneal Cancer | Adult CIRB - Late Phase Emphasis | Available to Open |
| NRG-GY033 | NRG | A Phase II Study of Androgen Receptor (AR) Inhibition by Darolutamide in Combination with Leuprolide Acetate and Exemestane in Recurrent Adult-Type Ovarian Granulosa Cell Tumor | Adult CIRB - Late Phase Emphasis | Available to Open |
| NRG-DT001 | NRG | A Phase Ib Trial of Neoadjuvant AMG 232 (KRT-232) Concurrent with Preoperative Radiotherapy in Wild-Type P53 Soft Tissue Sarcoma (STS) | Adult CIRB - Early Phase Emphasis | Available to Open |
| NRG-BN001 | NRG | Randomized Phase II Trial of Hypofractionated Dose-Escalated Photon IMRT or Proton Beam Therapy Versus Conventional Photon Irradiation With Concomitant and Adjuvant Temozolomide in Patients With Newly Diagnosed Glioblastoma | Adult CIRB - Late Phase Emphasis | Available to Open |