CIRB Studies
Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number | Lead Group | Study Title | CIRB | Study Status |
|---|---|---|---|---|
| ALTE1631 | COG | A Randomized Web-based Physical Activity Intervention among Children with Cancer | Pediatric CIRB | Available to Open |
| AOST06B1 | COG | A Children's Oncology Group Protocol for Collecting and Banking Osteosarcoma Specimens | Pediatric CIRB | Available to Open |
| ADVL1615 | COG | A Phase 1 Study of Pevonedistat (MLN4924, IND # 136078), A NEDD8 Activating Enzyme (NAE) Inhibitor, in Combination with Temozolomide and Irinotecan in Pediatric Patients with Recurrent or Refractory Solid Tumors | Pediatric CIRB | Available to Open |
| ACNS1931 | COG | A Phase 3 Study of Selumetinib (NSC# 748727, IND# 77782) or Selumetinib in Combination with Vinblastine for non-NF1, non-TSC Patients with Recurrent or Progressive Low-Grade Gliomas (LGGs) Lacking BRAFV600E or IDH1 Mutations | Pediatric CIRB | Available to Open |
| PBTC-058 | PBTC | Phase 2 Study of Intraventricular Omburtamab-based Radioimmunotherapy for Pediatric Patients with Recurrent Medulloblastoma and Ependymoma | Pediatric CIRB | Available to Open |
| ADVL0221 | COG | A Phase II Study of Trabectedin (ET-743; Yondelis) in Children with Recurrent Rhabdomyosarcoma; Ewing Sarcoma; or Nonrhabdomyosarcomatous Soft Tissue Sarcomas | Pediatric CIRB | Completed |
| ACNS2031 | COG | A Phase 3 Study of Sodium Thiosulfate for Reduction of Cisplatin-Induced Ototoxicity in Children with Average-Risk Medulloblastoma and Reduced Therapy in Children with Medulloblastoma with Low-Risk Features | Pediatric CIRB | Available to Open |
| AAML0523 | COG | A Phase I/II Study of CLOLAR® (Clofarabine, IND# 73,789) in Combination with Cytarabine in Pediatric Patients with Refractory/Relapsed Leukemia | Pediatric CIRB | Completed |
| AEPI05N1 | COG | Carcinogen Metabolism; DNA Repair; Parental Exposures and Retinoblastoma: A Groupwide Non-Therapeutic Study | Pediatric CIRB | Completed |
| ACCL0935 | COG | Prevention of Cancer/Treatment-Related Weight Loss in Children at High Nutritional Risk | Pediatric CIRB | Completed |