CIRB Studies
Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number | Lead Group | Study Title | CIRB | Study Status |
|---|---|---|---|---|
| 9952 | ETCTN | Phase 1 Trial to Determine the Recommended Phase 2 Dose (RP2D) of M6620 (VX‐970) When Combined with Whole Brain Radiotherapy (WBRT) in Patients with Brain Metastases from Lung Cancer | Adult CIRB - Early Phase Emphasis | Completed |
| 9653 | ETCTN | Phase II Trial of Gemcitabine-Eribulin (GE) in Cisplatin Ineligible Patients with Advanced or Unresectable Unrothelial Carcinoma of the Bladder | Adult CIRB - Early Phase Emphasis | Completed |
| ARST0531 | COG | Randomized Study of Vincristine; Dactinomycin and Cyclophosphamide (VAC) versus VAC Alternating with Vincristine and Irinotecan (VI) for Patients with Intermediate-Risk Rhabdomyosarcoma (RMS): A Groupwide Phase III Study | Pediatric CIRB | Completed |
| CALGB-49808 | CALGB | A 2 X 2 X 2 Factorial Randomized Phase III Trial of Multimodality Therapy Comparing 4 Cycles of Doxorubicin and Cyclophosphamide with or without Dexrazoxane (AC +/- Z) Followed by 12 Weeks of Weekly Paclitaxel with or without Trastuzumab (T H) Followed by Local Therapy Followed by 40 Weeks of Weekly Trastuzumab or none in Women with HER-2+ STAGE IIIA; IIIB or Regional Stage IV Breast Cancer **ADMINISTRATIVELY COMPLETED as of December 15; 2002** | Adult CIRB - Late Phase Emphasis | Completed |
| CALGB-90401 | CALGB | A Randomized Double-Blinded Placebo Controlled Phase III Trial Comparing Docetaxel and Prednisone with and without Bevacizumab (IND #7921; NSC #704865) in Men with Hormone Refractory Prostate Cancer | Adult CIRB - Late Phase Emphasis | Completed |
| RTOG-0232 | RTOG | A Phase III Study Comparing Combined External Beam Radiation and Transperineal Interstitial Permanent Brachytherapy with Brachytherapy Alone for Selected Patients with Intermediate Risk Prostatic Carcinoma | Adult CIRB - Late Phase Emphasis | Completed |
| 10247 | ETCTN | A Randomized Phase II Trial of MLN4924 (Pevonedistat) with Azacitidine versus Azacitidine in Adult Relapsed or Refractory Acute Myeloid Leukemia | Adult CIRB - Early Phase Emphasis | Completed |
| AALL06N1 | COG | A Study of Neurocognitive Function in Children Treated for ALL: A Group-wide; Non-Therapeutic Companion Study to AALL0232 | Pediatric CIRB | Completed |
| NCIC-BR.19 | NCIC CTG | A Phase III Prospective Randomized; Double-Blind; Placebo-Controlled Trial of the Epidermal Growth Factor Receptor Antagonist; ZD1839 (IRESSA) in Completely Resected Primary Stage IB; II and IIIA Non-Small Cell Lung Cancer | Adult CIRB - Late Phase Emphasis | Completed |
| ADVL06B1 | COG | A Pharmacokinetic-Pharmacodynamic-Pharmacogenetic Study of Actinomycin-D and Vincristine in Children with Cancer: A Group-Wide Non-Therapeutic Study | Pediatric CIRB | Completed |