CIRB Studies
Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number | Lead Group | Study Title | CIRB | Study Status |
|---|---|---|---|---|
| EA6134 | ECOG-ACRIN | DREAMseq (Doublet, Randomized Evaluation in Advanced Melanoma Sequencing) A Phase III Trial | Adult CIRB - Late Phase Emphasis | Available to Open |
| A082002 | Alliance | A Randomized Phase II/III Trial of Modern Immunotherapy Based Systemic Therapy with or without SBRT for PD-L1-Negative, Advanced Non-small Cell Lung Cancer | Adult CIRB - Late Phase Emphasis | Available to Open |
| ALTE16C1 | COG | Effects of Modern Chemotherapy Regimens on Spermatogenesis and Steroidogenesis in Adolescent and Young Adult (AYA) Survivors of Osteosarcoma | Pediatric CIRB | Available to Open |
| ADVL1414 | COG | A Phase 1 Study of Selinexor (KPT-330; IND #125052); A Selective XPO1 Inhibitor; In Recurrent and Refractory Pediatric Solid Tumors; Including CNS Tumors | Pediatric CIRB | Available to Open |
| S1900F | SWOG | A Randomized Phase II Study of Carboplatin and Pemetrexed with or Without Selpercatinib (LY3527723) in Participants with Non-Squamous RET Fusion-Positive Stage IV Non-Small Cell Lung Cancer and Progression of Disease on Prior RET Directed Therapy (Lung-MAP Sub-Study) | Adult CIRB - Late Phase Emphasis | Available to Open |
| S1702 | SWOG | A Phase II Study of Isatuximab (SAR650984) (NSC-795145) for Patients with Previously Treated AL Amyloidosis | Adult CIRB - Late Phase Emphasis | Available to Open |
| ANBL09P1 | COG | A COG Pilot Study of Intensive Induction Chemotherapy and 131I-MIBG Followed by Myeloablative Busulfan/Melphalan (Bu/Mel) for Newly Diagnosed High-Risk Neuroblastoma: A Limited Institution Pilot Study | Pediatric CIRB | Available to Open |
| 10553 | ETCTN | A Phase 2 Study of Darolutamide in Combination with Leuprolide Acetate in Hormone-Therapy Naïve Recurrent and/or Metastatic Androgen Receptor (AR) Positive Salivary Gland Cancer | Adult CIRB - Early Phase Emphasis | Available to Open |
| EAQ171CD | ECOG-ACRIN | Implementing a Virtual Tobacco Treatment in Community Oncology Practices: “Smoke Free Support Study 2.0” | Cancer Prevention and Control CIRB | Available to Open |
| NRG-BR009 | NRG | A Phase III Adjuvant Trial Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression plus Endocrine Therapy in Premenopausal Patients with pN0-1, ER Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score ≤ 25 (OFSET) | Adult CIRB - Late Phase Emphasis | Available to Open |