CIRB Studies
Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number | Lead Group | Study Title | CIRB | Study Status |
|---|---|---|---|---|
| 10222 | ETCTN | A Phase II study of olaparib and AZD6738 in isocitrate dehydrogenase (IDH) mutant solid tumors | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10221 | ETCTN | A Phase I/II Biomarker Driven Combination Trial of Copanlisib and Immune Checkpoint Inhibitors in patients with advanced solid tumors | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10220 | ETCTN | A Phase II Basket Trial of Glutaminase Inhibitor (BeGIN) CB-839 HCl in Patients with NF1 Aberrations, NF1 Mutant Malignant Peripheral Nerve Sheath Tumors (MPNST), KEAP1/NRF2 and LKB1 Aberrant Tumors | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10219 | ETCTN | Phase I Dose-Escalation and Dose-Expansion Trial of a Novel Glutaminase Inhibitor (CB-839 HCl) in Combination with Carfilzomib and Dexamethasone in Relapsed and/or Refractory Multiple Myeloma | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10218 | ETCTN | A Phase 1b Trial of CB-839 in Combination with Radiation Therapy and Temozolomide in Patients with IDH-mutated Diffuse Astrocytoma and Anaplastic Astrocytoma | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10217 | ETCTN | A Phase 1b Biomarker-Driven Combination Trial of Copanlisib, Olaparib, and MEDI4736 (Durvalumab) in Patients with Advanced Solid Tumors | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10216 | ETCTN | A Phase I/II Study of AZD9291 (Osimertinib) and CB-839 HCl in Patients with EGFR Mutant Non-Small Cell Lung Cancer | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10214 | ETCTN | Immune Checkpoint Blockade for Kidney Transplant Recipients with Selected Unresectable or Metastatic Cancers | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10212 | ETCTN | A Phase 1b/2 study of Pinometostat in Combination with standard induction chemotherapy in newly diagnosed Acute Myeloid Leukemia with MLL rearrangement | Adult CIRB - Early Phase Emphasis | Completed |
| 10211 | ETCTN | A Phase 2 Single-Arm Study of M6620 in Combination with Irinotecan in Patients with Progressive TP53 Mutant Gastric and Gastro-Esophageal Junction Cancer | Adult CIRB - Early Phase Emphasis | Available to Open |