CIRB Studies
Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number | Lead Group | Study Title | CIRB | Study Status |
|---|---|---|---|---|
| 10061 | ETCTN | A Phase 1 Study of MK-3475 (Pembrolizumab) in Combination with Recombinant Interleukin-12 in Patients with Solid Tumors | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10273 | ETCTN | A Phase 1 Study of M3814 in combination with MEC in Patients with Relapsed or Refractory Acute Myeloid Leukemia | Adult CIRB - Early Phase Emphasis | Available to Open |
| ADVL1515 | COG | A Phase 1 Study of LY2606368, (prexasertib mesylate monohydrate) (IND# 132233), a CHK1/2 Inhibitor, in Pediatric Patients with Recurrent or Refractory Solid Tumors, including CNS Tumors | Pediatric CIRB | Completed |
| 10335 | ETCTN | A Phase 1 Study of Lenalidomide in Combination with EPOCH Chemotherapy for HTLV-Associated Adult T-Cell Leukemia-Lymphoma (ATLL) | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10026 | ETCTN | A Phase 1 Study of Ipilimumab in Combination with Decitabine in Relapsed or Refractory Myelodysplastic Syndrome/Acute Myeloid | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10410 | ETCTN | A Phase 1 Study of IPdR in Combination with Capecitabine and Radiotherapy in Rectal Cancer | Adult CIRB - Early Phase Emphasis | Completed |
| ADVL1314 | COG | A Phase 1 Study of Eribulin Mesylate (E7389; IND #116;292); A Novel Microtubule Targeting Chemotherapeutic Agent in Children with Refractory or Recurrent Solid Tumors (Excluding CNS); Including Lymphomas: A Participation Limited to the COG Phase 1 Consortium | Pediatric CIRB | Completed |
| ADVL1513 | COG | A Phase 1 Study of Entinostat; An Oral Histone Deacetylase Inhibitor; In Pediatric Patients with Recurrent or Refractory Solid Tumors; Including CNS Tumors and Lymphoma | Pediatric CIRB | Completed |
| 10399 | ETCTN | A Phase 1 Study of Entinostat in Combination with Atezolizumab / Carboplatin / Etoposide in Previously Untreated Extensive-Stage Small Cell Lung Cancer | Adult CIRB - Early Phase Emphasis | Available to Open |
| 9681 | ETCTN | A Phase 1 Study of Cabozantinib plus Nivolumab (CaboNivo) Alone or in Combination with Ipilimumab (CaboNivoIpi) in Patients with Advanced/Metastatic Urothelial Carcinoma and other Genitourinary Tumors. | Adult CIRB - Early Phase Emphasis | Available to Open |