CIRB Studies
Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number | Lead Group | Study Title | CIRB | Study Status |
|---|---|---|---|---|
| E1900 | ECOG | A Phase III Trial in Adult Acute Myeloid Leukemia: Daunorubicin Dose-<br>Intensification Prior to Risk-Allocated Autologous Stem Cell Transplantation | Adult CIRB - Late Phase Emphasis | Available to Open |
| S1905 | SWOG | A Phase I/II Study of AKR1C3-Activated Prodrug OBI‐3424 (OBI-3424) in Patients with Relapsed/Refractory T-Cell Acute Lymphoblastic Leukemia (T-ALL)/T-Cell Lymphoblastic Lymphoma (T-LBL) | Adult CIRB - Late Phase Emphasis | Available to Open |
| S2012 | SWOG | Randomized Phase II/III Trial of First Line Platinum/Etoposide with or without Atezolizumab (NSC #783608) in Patients with Poorly Differentiated Extrapulmonary Small Cell Neuroendocrine Carcinomas (NEC) | Adult CIRB - Late Phase Emphasis | Available to Open |
| 10499 | ETCTN | Phase Ib/II study of ZEN003694 and entinostat in advanced and refractory solid tumors and lymphomas | Adult CIRB - Early Phase Emphasis | Available to Open |
| 9608 | ETCTN | A Phase I Trial of ABT-263 (Navitoclax); a Bcl-2 inhibitor; and Sorafenib (Nexavar) in Patients with Relapsed or Refractory Solid Organ Tumors | Adult CIRB - Early Phase Emphasis | Available to Open |
| ABTR04B1 | COG | Establishing Continuous Cell Lines and Xenografts from Pediatric Cancers for Biological and Pre-Clinical Therapeutic Studies | Pediatric CIRB | Available to Open |
| 10558 | ETCTN | A Phase II Randomized Control Trial of Triapine Plus Lutetium Lu 177 Dotatate Versus Lutetium Lu 177 Dotatate Alone for Well-Differentiated Somatostatin Receptor-Positive Neuroendocrine Tumors | Adult CIRB - Early Phase Emphasis | Available to Open |
| EAY191-A6 | ECOG-ACRIN | A ComboMATCH Treatment Trial: FOLFOX in Combination with Binimetinib as 2nd Line Therapy for Patients with Advanced Biliary Tract Cancers with MAPK Pathway Alterations | Adult CIRB - Early Phase Emphasis | Available to Open |
| A011202 | Alliance | A Randomized Phase III Trial Comparing Axillary Lymph Node Dissection to Axillary Radiation in Breast Cancer Patients (cT1-3 N1) Who Have Positive Sentinel Lymph Node Disease After Neoadjuvant Chemotherapy | Adult CIRB - Late Phase Emphasis | Available to Open |
| A021804 | Alliance | A Prospective, Multi-Institutional Phase II Trial Evaluating Temozolomide vs Temozolomide and Olaparib for Advanced Pheochromocytoma and Paraganglioma | Adult CIRB - Late Phase Emphasis | Available to Open |