CIRB Studies
Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number | Lead Group | Study Title | CIRB | Study Status |
|---|---|---|---|---|
| E1A11 | ECOG | Randomized Phase III Trial of Bortezomib; LENalidomide and Dexamethasone (VRd) Versus Carfilzomib; Lenalidomide and Dexamethasone (CRd) Followed by Limited or Indefinite DURation Lenalidomide MaintenANCE in Patients with Newly Diagnosed Symptomatic Multiple Myeloma (ENDURANCE) | Adult CIRB - Late Phase Emphasis | Available to Open |
| ADVL1414 | COG | A Phase 1 Study of Selinexor (KPT-330; IND #125052); A Selective XPO1 Inhibitor; In Recurrent and Refractory Pediatric Solid Tumors; Including CNS Tumors | Pediatric CIRB | Available to Open |
| E4A03 | ECOG | A Randomized Phase III Study of CC-5013 Plus Dexamethasone Versus CC-5013 Plus Low Dose Dexamethasone in Multiple Myeloma with Thalidomide Plus Dexamethasone Salvage Therapy for Non-Responders | Adult CIRB - Late Phase Emphasis | Available to Open |
| A151216 | Alliance | Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trial (ALCHEMIST) | Adult CIRB - Late Phase Emphasis | Available to Open |
| MDA20-01-01 | CP-CTNet_CLO-MD Anderson | A Phase IIa, Placebo-Controlled, Randomized Study of Daily Obeticholic Acid (OCA) to Reduce Intestinal Polyp Burden in Familial Adenomatous Polyposis (FAP) | Cancer Prevention and Control CIRB | Available to Open |
| S1826 | SWOG | A Phase III, Randomized Study of Nivolumab (Opdivo) plus AVD or Brentuximab Vedotin (Adcetris) plus AVD in Patient (Age >/= 12 Year) with Newly Diagnosed Advanced Stage Classical Hodgkin Lymphoma | Adult CIRB - Late Phase Emphasis | Available to Open |
| NRG-BN007 | NRG | A Randomized Phase II/III Open-Label Study of Ipilimumab and Nivolumab versus Temozolomide in Patients with Newly Diagnosed MGMT (Tumor O-6-Methylganine DNA Methyltransferase) Unmethylated Glioblastoma | Adult CIRB - Late Phase Emphasis | Available to Open |
| NWU21-08-01 | CLO-Northwestern University | Phase II Trial of Oral Iloprost for the Precision Chemoprevention of Lung Cancer | Cancer Prevention and Control CIRB | Available to Open |
| ACNS1723 | COG | A Phase 2 Study of Dabrafenib (NSC# 763760) with Trametinib (NSC# 763093) after Local Irradiation in Newly-Diagnosed BRAFV600-Mutant High-Grade Glioma (HGG) (IND# 145355) | Pediatric CIRB | Available to Open |
| A191901 | Alliance | Optimizing Endocrine Therapy Through Motivational Interviewing and Text Interventions | Cancer Prevention and Control CIRB | Available to Open |