CIRB Studies
Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number | Lead Group | Study Title | CIRB | Study Status |
|---|---|---|---|---|
| PBTC-055 | PBTC | Phase I/II trial of Dabrafenib, Trametinib, and Hydroxychloroquine (HCQ) for BRAF V600E-mutant or Trametinib and HCQ for BRAF fusion/duplication positive or NF1-associated recurrent or progressive gliomas in children and young adults | Pediatric CIRB | Available to Open |
| ANBL1232 | COG | Utilizing Response- and Biology-Based Risk Factors to Guide Therapy in Patients with Non-High-Risk Neuroblastoma. A Groupwide Historically Controlled Phase III Study | Pediatric CIRB | Available to Open |
| GOG-0281 | GOG | A Randomized Phase II/III Study To Assess The Efficacy of Trametinib (GSK 1120212) In Patients With Recurrent Or Progressive Low-Grade Serous Ovarian Cancer Or Peritoneal Cancer. NCT # NCT02101788 | Adult CIRB - Late Phase Emphasis | Available to Open |
| 10366 | ETCTN | A Phase 1/2 Study of M3814 (peposertib) in Combination with Hypofractionated Radiotherapy for the Treatment of Locally Advanced Pancreatic Adenocarcinoma | Adult CIRB - Early Phase Emphasis | Available to Open |
| ANBL19P1 | COG | A Pilot Study of Dinutuximab, Sargramostim (GM-CSF), and Isotretinoin in Combination with Irinotecan and Temozolomide in the Post-Consolidation Setting for High-Risk Neuroblastoma | Pediatric CIRB | Available to Open |
| 10355 | ETCTN | A phase I study of DS-8201a in combination with olaparib in HER2-expressing malignancies | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10434 | ETCTN | Randomized Phase 2 Study of CPX-351 + Pomalidomide versus CPX-351 in Newly Diagnosed AML with MDS-Related Changes | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10026 | ETCTN | A Phase 1 Study of Ipilimumab in Combination with Decitabine in Relapsed or Refractory Myelodysplastic Syndrome/Acute Myeloid | Adult CIRB - Early Phase Emphasis | Available to Open |
| ADVL1622 | COG | Phase 2 Trial of XL184 (Cabozantinib); an Oral Small-Molecule Inhibitor of Multiple Kinases; in Children and Young Adults with Refractory Sarcomas; Wilms Tumor; and Other Rare Tumors | Pediatric CIRB | Available to Open |
| NWU20-04-01 | CLO-Northwestern University | Metformin for Chemoprevention of Lung Cancer in High-Risk Overweight or Obese Individuals | Cancer Prevention and Control CIRB | Available to Open |