CIRB Studies
Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number | Lead Group | Study Title | CIRB | Study Status |
|---|---|---|---|---|
| NRG-LU002 | NRG | Maintenance Systemic Therapy versus Local Consolidative Therapy (LCT) Plus Maintenance Systemic Therapy for Limited Metastatic Non-Small Cell Lung Cancer (NSCLC): A Randomized Phase II/III Trial | Adult CIRB - Late Phase Emphasis | Available to Open |
| 10219 | ETCTN | Phase I Dose-Escalation and Dose-Expansion Trial of a Novel Glutaminase Inhibitor (CB-839 HCl) in Combination with Carfilzomib and Dexamethasone in Relapsed and/or Refractory Multiple Myeloma | Adult CIRB - Early Phase Emphasis | Available to Open |
| S1802 | SWOG | Phase III Randomized Trial of Standard Systemic Therapy (SST) versus Standard Systemic Therapy Plus Definitive Treatment (Surgery or Radiation) of the Primary Tumor in Metastatic Prostate Cancer | Adult CIRB - Late Phase Emphasis | Available to Open |
| 10476 | ETCTN | A Randomized Phase 2 Study of Combination Atezolizumab and CDX-1127 (Varlilumab) With or Without Addition of Cobimetinib in Previously Treated Unresectable Biliary Tract Cancers | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10015 | ETCTN | A Non-Randomized; Open-Label; Phase 2 Study of Trametinib in Patients with Unresectable or Metastatic Epithelioid Hemangioendothelioma | Adult CIRB - Early Phase Emphasis | Available to Open |
| A032001 | Alliance | MAIN-CAV: Phase III Randomized Trial of Maintenance Cabozantinib and Avelumab vs Maintenance Avelumab After First-Line Platinum-Based Chemotherapy in Patients with Metastatic Urothelial Cancer | Adult CIRB - Late Phase Emphasis | Available to Open |
| A221505 | Alliance | RT Charm: Phase III Randomized Trial of Hypofractionated Post Mastectomy Radiation with Breast Reconstruction | Cancer Prevention and Control CIRB | Available to Open |
| DCP-002 | NCI | Early Onset Malignancy Initiative (EOMI): Molecular Profiling of Breast; Prostate; Colorectal; Liver; Kidney; and Multiple Myeloma Among Racially and Ethnically Diverse Populations | Adult CIRB - Early Phase Emphasis | Available to Open |
| NSABP-NCIC-CTG-MA.32.F | NSABP | Biobehavioral Mechanisms of Fatigue in Patients Treated on NCIC CTG MA.32: A Phase III Randomized Trial of Metformin Versus Placebo on Recurrence and Survival in Early Stage Breast Cancer | Adult CIRB - Late Phase Emphasis | Available to Open |
| EA8212 | ECOG-ACRIN | A Randomized Phase III Trial of Intravesical BCG veRsus Intravesical Docetaxel and GEmcitabine Treatment in BCG Naïve High Grade Non-Muscle Invasive Bladder Cancer (BRIDGE) | Adult CIRB - Late Phase Emphasis | Available to Open |