CIRB Studies
Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number | Lead Group | Study Title | CIRB | Study Status |
|---|---|---|---|---|
| ANBL1221 | COG | A Phase II Randomized Trial of Irinotecan/Temozolomide with Temsirolimus (NSC# 683864; IND# 61010) or Chimeric 14.18 Antibody (ch14.18) (NSC# 764038; IND# 4308) in Children with Refractory; Relapsed or Progressive Neuroblastoma | Pediatric CIRB | Completed |
| S2200 | SWOG | A Phase II Randomized Trial of Cabozantinib (NSC #761968) with or without Atezolizumab (NSC #783608) in Patients with Advanced Papillary Renal Cell Carcinoma (PAPMET2) | Adult CIRB - Late Phase Emphasis | Available to Open |
| EA3191 | ECOG-ACRIN | A Phase II Randomized Trial of Adjuvant Therapy with Pembrolizumab after Resection of Recurrent/Second Primary Head and Neck Squamous Cell Carcinoma with High Risk Features | Adult CIRB - Late Phase Emphasis | Available to Open |
| 10147 | ETCTN | A Phase II randomized study of topotecan/carboplatin with or without veliparib in advanced myeloproliferative disorders and chronic myelomonocytic leukemia (CMML). | Adult CIRB - Early Phase Emphasis | Available to Open |
| S1800A | SWOG | A Phase II Randomized Study of Ramucirumab plus MK3475 (Pembrolizumab) versus Standard of Care for Patients Previously Treated with Immunotherapy for Stage IV or Recurrent Non-Small Cell Lung Cancer (Lung-MAP Non-Matched Sub-Study) | Adult CIRB - Late Phase Emphasis | Available to Open |
| S1616 | SWOG | A Phase II Randomized Study of Nivolumab (NSC-748726) with Ipilimumab (NSC-732442) or Ipilimumab Alone in Advanced Melanoma Patients Refractory to an Anti-PD1 or Anti-PD-L1 Agent | Adult CIRB - Late Phase Emphasis | Available to Open |
| S2005 | SWOG | A Phase II Randomized Study of Ibrutinib and Rituximab with or without Venetoclax in Previously Untreated Waldenström's Macroglobulinemia (WM)/Lymphoplasmacytic Lymphoma (LPL) | Adult CIRB - Late Phase Emphasis | Available to Open |
| S1801 | SWOG | A Phase II Randomized Study of Adjuvant versus Neoadjuvant MK-3475 (Pembrolizumab) for Clinically Detectable Sage III-IV High Risk Melanoma | Adult CIRB - Late Phase Emphasis | Available to Open |
| EA8184 | ECOG-ACRIN | A Phase II Randomized Double Blinded Study of Green Tea Catechins (GTC) vs. Placebo in Men on Active Surveillance for Prostate Cancer: Modulation of Biological and Clinical Intermediate Biomarkers | Cancer Prevention and Control CIRB | Available to Open |
| 10558 | ETCTN | A Phase II Randomized Control Trial of Triapine Plus Lutetium Lu 177 Dotatate Versus Lutetium Lu 177 Dotatate Alone for Well-Differentiated Somatostatin Receptor-Positive Neuroendocrine Tumors | Adult CIRB - Early Phase Emphasis | Available to Open |