CIRB Studies
Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number | Lead Group | Study Title | CIRB | Study Status |
|---|---|---|---|---|
| 10405 | ETCTN | Phase I Trial of BAY 1895344 ATR Inhibitor Combined with Stereotactic Body Radiation Therapy and Pembrolizumab for Recurrent Head and Neck Squamous Cell Carcinoma | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10495 | ETCTN | Phase I Trial of DS-8201a (Trastuzumab Deruxtecan) in Combination with Neratinib in Solid Tumors with HER2 Alterations | Adult CIRB - Early Phase Emphasis | Available to Open |
| NWU2017-09-01 | CLO-Northwestern University | Phase I trial of endoxifen gel versus placebo gel in women undergoing breast surgery | Cancer Prevention and Control CIRB | Available to Open |
| A051901 | Alliance | Phase I Trial of Methotrexate, Rituximab, Lenalidomide, and Nivolumab (NIVO-MR2) Induction Followed by Lenalidomide and Nivolumab Maintenance in Primary CNS Lymphoma | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10579 | ETCTN | Phase I trial of ZEN003694 (ZEN-3694) in combination with capecitabine in patients with solid tumors | Adult CIRB - Early Phase Emphasis | Available to Open |
| NRG-HN008 | NRG | Phase I Trial with Expansion Cohort of DNA-PK Inhibition and IMRT in Cisplatin-Ineligible Patients with Stage 3-4 Local-Regionally Advanced Head and Neck Squamous Cell Carcinoma (HNSCC) | Adult CIRB - Early Phase Emphasis | Available to Open |
| NRG-GI007 | NRG | Phase I Trial with Expansion Cohort of OBP-301 (Telomelysin™) and Definitive Chemoradiation for Patients with Locally Advanced Esophageal and Gastroesophageal Adenocarcinoma Who Are Not Candidates for Surgery | Adult CIRB - Late Phase Emphasis | Available to Open |
| NRG-GY027 | NRG | Phase I/IB Safety and Pharmacodynamic Study of Neoadjuvant (NACT) Paclitaxel and Carboplatin with Ipatasertib as Initial Therapy of Ovarian Cancer PTMA 100805 | Adult CIRB - Late Phase Emphasis | Available to Open |
| 10433 | ETCTN | Phase I/Ib trial evaluating the safety and efficacy of BET inhibitor, ZEN003694 with PD-1 inhibitor, nivolumab with or without CTLA-4 inhibitor, ipilimumab in solid tumors | Adult CIRB - Early Phase Emphasis | Available to Open |
| 9466 | ETCTN | Phase I/II study of dabrafenib, trametinib, and navitoclax in BRAF mutant melanoma (Phase I and II) and other solid tumors (Phase I only) | Adult CIRB - Early Phase Emphasis | Available to Open |