CIRB Studies
Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number | Lead Group | Study Title | CIRB | Study Status |
|---|---|---|---|---|
| 10528 | ETCTN | A Phase 1 Study of the Polymerase Theta (POLθ) Inhibitor Novobiocin in BRCA-mutant and Other DNA Damage Repair-Deficient Solid Tumors | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10527 | ETCTN | A Molecularly Driven Phase 1b Dose Escalation and Dose Expansion Study of the DNA-PK Inhibitor Peposertib (M3814) in Combination with the ATR Inhibitor M1774 | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10525 | ETCTN | A Phase 1b Trial of ZEN003694 (ZEN-3694) with Pembrolizumab and Nab-Paclitaxel in Patients with Metastatic Triple-Negative Breast Cancer | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10522 | ETCTN | A Phase 1 Clinical Trial of CA-4948 in Combination with Gemcitabine and Nab-Paclitaxel in Metastatic or Unresectable Pancreatic Ductal Carcinoma | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10517 | ETCTN | An Open Label, Randomized Phase II Study Neoadjuvant Erdafitinib with or without Atezolizumab in Cisplatin-Ineligible Patients with Muscle Invasive Bladder Cancer (NERA) | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10512 | ETCTN | A Phase 2 Randomized Study of the BER Inhibitor TRC102 in Combination with Standard Pemetrexed-Platinum-Radiation in Stage III Non-Squamous Non-Small Cell Lung Cancer | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10509 | ETCTN | A Phase 1 Study of BET Bromodomain Inhibitor ZEN003694 in Combination with the CDK4/6 Inhibitor Abemaciclib in Patients with NUT Carcinoma and Other Solid Tumors | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10508 | ETCTN | A Phase 1 Study of Nivolumab in Combination with ASTX727 in B-cell lymphoma (NHL or HL) with an Expansion Cohort in Relapsed or Refractory Diffuse Large B-Cell Lymphoma (DLBCL) | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10507 | ETCTN | A Phase 1/2 Study of the Bromodomain Inhibitor ZEN003694 in Combination with Etoposide/Platinum in Patients with NUT Carcinoma | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10505 | ETCTN | A Phase 1/2 Trial of Selinexor and Temozolomide in Recurrent Glioblastoma | Adult CIRB - Early Phase Emphasis | Available to Open |