CIRB Studies
Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number | Lead Group | Study Title | CIRB | Study Status |
|---|---|---|---|---|
| ABTC-1801 | ABTC | Phase I/II Study of Pamiparib (BGB-290) with Temozolomide in Recurrent Gliomas with IDH1/2 Mutations | Adult CIRB - Early Phase Emphasis | Available to Open |
| PBTC-055 | PBTC | Phase I/II trial of Dabrafenib, Trametinib, and Hydroxychloroquine (HCQ) for BRAF V600E-mutant or Trametinib and HCQ for BRAF fusion/duplication positive or NF1-associated recurrent or progressive gliomas in children and young adults | Pediatric CIRB | Available to Open |
| UWI2015-05-01 | CP-CTNet_CLO-University of Wisconsin | Phase Ib 9cUAB30 in Early Stage Breast Cancer to Evaluate Biologic Effect | Cancer Prevention and Control CIRB | Available to Open |
| 10483 | ETCTN | Phase Ib trial of Erdafitinib combined with Enfortumab Vedotin following platinum and PD1/L1 inhibitors for metastatic urothelial carcinoma with FGFR2/3 genetic alterations | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10480 | ETCTN | Phase Ib/II Study of EPA-based EphA2 Targeted Therapy for Patients with Metastatic Triple-Negative Inflammatory Breast Cancer | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10499 | ETCTN | Phase Ib/II study of ZEN003694 and entinostat in advanced and refractory solid tumors and lymphomas | Adult CIRB - Early Phase Emphasis | Available to Open |
| 10296 | ETCTN | Phase Ib/II trial of copanlisib in combination with trastuzumab and pertuzumab after induction treatment of HER2 positive (HER2+) metastatic breast cancer (MBC) with PIK3CA mutation or PTEN mutation | Adult CIRB - Early Phase Emphasis | Completed |
| NRG-CC004 | NRG | Phase II Double Blind Dose Finding Trial of Bupropion Versus Placebo for Sexual Desire In Women With Breast or Gynecologic Cancer | Cancer Prevention and Control CIRB | Completed |
| EAF223 | ECOG-ACRIN | Phase II Glioblastoma Accelerated Biomarkers Learning Environment Trial (GABLE) | Adult CIRB - Late Phase Emphasis | Available to Open |
| S1416 | SWOG | Phase II Randomized Placebo-Controlled Trial of Cisplatin with or without ABT-888 (Veliparib) in Metastatic Triple-Negative Breast Cancer and/or BRCA Mutation-Associated Breast Cancer with or Without Brain Metastases | Adult CIRB - Late Phase Emphasis | Available to Open |