CIRB Studies
Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number | Lead Group | Study Title | CIRB | Study Status |
|---|---|---|---|---|
| NSABP-B-52 | NSABP | A Randomized Phase III Trial Evaluating Pathologic Complete Response Rates in Patients with Hormone Receptor-Positive; HER2-Positive; Large Operable and Locally Advanced Breast Cancer Treated with Neoadjuvant Therapy of Docetaxel; Carboplatin; Trastuzumab; and Pertuzumab (TCHP) With or Without Estrogen Deprivation | Adult CIRB - Late Phase Emphasis | Completed |
| NSABP-B-34 | NSABP | A Clinical Trial Comparing Adjuvant Clodronate Therapy vs. Placebo in Early-Stage Breast Cancer Patients Receiving Systemic Chemotherapy and/or Hormonal Therapy or No Therapy | Adult CIRB - Late Phase Emphasis | Completed |
| RTOG-0522 | RTOG | A Randomized Phase III Trial of Concurrent Accelerated Radiation and Cisplatin Versus Concurrent Accelerated Radiation; Cisplatin and Cetuximab (C225) [Followed by Surgery for Selected Patients] For Stage III and IV Head and Neck Carcinomas<br> | Adult CIRB - Late Phase Emphasis | Completed |
| RTOG-1112 | RTOG | Randomized Phase III Study of Sorafenib Versus Stereotactic Body Radiation Therapy Followed by Sorafenib in Hepatocellular Carcinoma | Adult CIRB - Late Phase Emphasis | Available to Open |
| RTOG-0412-SWOG-S0332 | RTOG | Phase III Randomized Trial of Preoperative Chemotherapy Versus Preoperative Concurrent Chemotherapy and Thoracic Radiotherapy Followed by Surgical Resection and Consolidation Chemotherapy in Favorable Prognosis Patients With Stage IIIA (N2) Non-Small Cell Lung Cancer | Adult CIRB - Late Phase Emphasis | Completed |
| NRG-HN001 | RTOG | Randomized Phase II and Phase III Studies of Individualized Treatment for Nasopharyngeal Carcinoma Based on Biomarker Epstein Barr Virus (EBV) Deoxyribonucleic Acid (DNA) | Adult CIRB - Late Phase Emphasis | Available to Open |
| RTOG-0848 | RTOG | A Phase II-R and A Phase III Trial Evaluating Both Erlotinib (Ph II-R) and Chemoradiation (Ph III) as Adjuvant Treatment for Patients with Resected Head of Pancreas Adenocarcinoma <br> | Adult CIRB - Late Phase Emphasis | Available to Open |
| RTOG-0525 | RTOG | Phase III Trial Comparing Conventional Adjuvant Temozolomide with Dose-Intensive Temozolomide in Patients with Newly Diagnosed Glioblastoma | Adult CIRB - Late Phase Emphasis | Completed |
| RTOG-0415 | RTOG | A Phase III Randomized Study of Hypofractionated 3D-CRT/IMRT versus Conventionally Fractionated 3D-CRT/IMRT in Patients with Favorable-Risk Prostate Cancer | Adult CIRB - Late Phase Emphasis | Available to Open |
| RTOG-1115 | RTOG | Phase III Trial of Dose Escalated Radiation Therapy and Standard Androgen Deprivation Therapy (ADT) with a GnRH Agonist vs. Dose Escalated Radiation Therapy and Enhanced ADT with a GnRH Agonist and TAK-700 For Men with High Risk Prostate Cancer | Adult CIRB - Late Phase Emphasis | Available to Open |