CIRB Studies
Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number | Lead Group | Study Title | CIRB | Study Status |
|---|---|---|---|---|
| EA1181 | ECOG-ACRIN | (CompassHER2-pCR): Preoperative THP and postoperative HP in patients who achieve a pathologic complete response | Adult CIRB - Late Phase Emphasis | Available to Open |
| A021806 | Alliance | A Phase III Trial of Perioperative versus Adjuvant Chemotherapy for Resectable Pancreatic Cancer | Adult CIRB - Late Phase Emphasis | Available to Open |
| NSABP-R-04 | NSABP | A Clinical Trial Comparing Preoperative Radiation Therapy and Capecitabine with or without Oxaliplatin with Preoperative Radiation Therapy and Continuous Intravenous Infusion of 5-Fluorouracil with or without Oxaliplatin in the Treatment of Patients with Operable Carcinoma of the Rectum | Adult CIRB - Late Phase Emphasis | Completed |
| ACOSOG-Z1041 | ACSOG | A Randomized Phase III Trial Comparing a Neoadjuvant Regimen of FEC-75 Followed by Paclitaxel Plus Trastuzumab With a Neoadjuvant Regimen of Paclitaxel Plus Trastuzumab Followed by FEC-75 Plus Trastuzumab in Patients with HER-2 Positive Operable Breast Cancer | Adult CIRB - Late Phase Emphasis | Completed |
| NRG-GY011 | NRG | A Randomized Surgical Window Pilot Investigation of the Relationship of Short Term Medroxyprogesterone Acetate (NSC #26386) Compared to Medroxyprogesterone Acetate Plus Entinostat (NSC #706995) on the Morphologic, Biochemical, and Molecular Changes in Primary Endometrioid Adenocarcinoma of the Uterine Corpus | Adult CIRB - Late Phase Emphasis | Completed |
| E4512 | ECOG | A Randomized Phase III Trial for Surgically Resected Early Stage Non-Small Cell Lung Cancer: Crizotinib versus Observation for Patients with Tumors Harboring the Anaplastic Lymphoma Kinase (ALK) Fusion Protein | Adult CIRB - Late Phase Emphasis | Available to Open |
| A081801 | Alliance | Integration of Immunotherapy into Adjuvant Therapy for Resected NSCLC: ALCHEMIST Chemo-IO | Adult CIRB - Late Phase Emphasis | Available to Open |
| NSABP-B-33 | NSABP | A Randomized; Placebo-Controlled; Double-Blind Trial Evaluating the Effect of Exemestane in Clinical Stage T1-3N0-1M0 Postmenopausal Breast Cancer Patients Completing at Least Five Years of Tamoxifen Therapy | Adult CIRB - Late Phase Emphasis | Completed |
| NRG-HN007 | NRG | An Open-Label, Phase III Study of Platinum-Gemcitabine with or without Nivolumab in the First-Line Treatment of Recurrent or Metastatic Nasopharyngeal Carcinoma | Adult CIRB - Late Phase Emphasis | Completed |
| RTOG-0815 | RTOG | A Phase III Prospective Randomized Trial of Dose-Escalated Radiotherapy With or Without Short-Term Androgen Deprivation Therapy for Patients With Intermediate-Risk Prostate Cancer | Adult CIRB - Late Phase Emphasis | Available to Open |