Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
|Study Number||Lead Group||Study Title||CIRB||Study Status|
|AOST1321||COG||Phase II Study of Denosumab (IND #127430; NSC# 744010); a RANK Ligand Antibody; for Recurrent or Refractory Osteosarcoma||Pediatric CIRB||Available to Open|
|ASCT0431||COG||A Randomized Trial of Sirolimus-Based Graft versus Host Disease Prophylaxis after Hematopoietic Stem Cell Transplantation in Selected Patients with CR1 and CR2 ALL: A Groupwide Phase III Study||Pediatric CIRB||Completed|
|ABTR04B1||COG||Establishing Continuous Cell Lines and Xenografts from Pediatric Cancers for Biological and Pre-Clinical Therapeutic Studies||Pediatric CIRB||Available to Open|
|ACNS0927||COG||A Phase 1/2 Study of Suberoylanilide Hydroxamic Acid (SAHA; Vorinostat) and Local Irradiation; Followed By Maintenance SAHA in Children with Newly Diagnosed Diffuse Intrinsic Pontine Gliomas (DIPG)||Pediatric CIRB||Available to Open|
|AALL1731||COG||A Phase 3 Trial Investigating Blinatumomab (IND# 117467, NSC# 765986) in Combination with Chemotherapy in Patients with Newly Diagnosed Standard Risk or Down syndrome B-Lymphoblastic Leukemia (B-ALL) and the Treatment of Patients with Localized B-Lymphoblastic Lymphoma (B-LLy)||Pediatric CIRB||Available to Open|
|AAML0121||COG||"A Phase II Study of Amifostine In Children with Myelodysplastic Syndrome: A Group-wide Study"||Pediatric CIRB||Completed|
|ARAR0332||COG||Treatment of Adrenocortical Tumors with Surgery plus Lymph Node Dissection and Multiagent Chemotherapy: A Groupwide Phase III Study||Pediatric CIRB||Available to Open|
|AREN1721||COG||A Randomized Phase 2 Trial of Axitinib/Nivolumab Combination Therapy vs. Single Agent Axitinib or Nivolumab for the Treatment of TFE/Translocation Renal Cell Carcinoma (tRCC) Across All Age Groups||Pediatric CIRB||Available to Open|
|AEWS0521||COG||A Randomized Phase II Study of Bevacizumab (NSC 704865; BB-IND# 7921) Combined with Vincristine; Topotecan and Cyclophosphamide in Patients with First Recurrent Ewing Sarcoma||Pediatric CIRB||Completed|
|ASCT0631||COG||A Phase III Randomized Trial of G-CSF Stimulated Bone Marrow vs. Conventional Bone Marrow as a Stem Cell Source In Matched Sibling Donor Transplantation||Pediatric CIRB||Available to Open|