Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
|Study Number||Lead Group||Study Title||CIRB||Study Status|
|ACCL05C1||COG||A Group-Wide; Prospective Study of Ototoxicity Assessment in Children Receiving Cisplatin Chemotherapy||Pediatric CIRB||Completed|
|ADVL1614||COG||A Phase 1/2 Study of VX15/2503 in Children, Adolescents, or Young Adults with Recurrent or Relapsed Solid Tumors||Pediatric CIRB||Available to Open|
|ADVL0821||COG||A Phase II Study of IMC-A12 (Anti-IGF-I Receptor Monoclonal Antibody; IND# 100947; NSC# 742460) in Children with Relapsed/Refractory Solid Tumors: A COG Groupwide Phase II Study||Pediatric CIRB||Completed|
|AOST06P1||COG||Feasibility and Dose Discovery Analysis of Zoledronic Acid with Concurrent Chemotherapy in the Treatment of Newly Diagnosed Metastatic Osteosarcoma: A Groupwide Pilot Study||Pediatric CIRB||Completed|
|ACNS1723||COG||A Phase 2 Study of Dabrafenib (NSC# 763760) with Trametinib (NSC# 763093) after Local Irradiation in Newly-Diagnosed BRAFV600-Mutant High-Grade Glioma (HGG) (IND# 145355)||Pediatric CIRB||Available to Open|
|ANBL1821||COG||A Phase 2 Randomized Study of Irinotecan/Temozolomide/Dinutuximab with or without Eflornithine (DFMO) (IND# TBD) in Children with Relapsed, Refractory or Progressive Neuroblastoma||Pediatric CIRB||Available to Open|
|ALTE1621||COG||Pharmacologic Reversal of Ventricular Remodeling in Childhood Cancer Survivors at Risk for Heart Failure (PREVENT-HF): A Phase 2b Randomized Placebo-Controlled (Carvedilol) Trial||Pediatric CIRB||Available to Open|
|ACNS1721||COG||A Phase 2 Study of Veliparib (ABT-888, IND # 139199) and Local Irradiation, Followed by Maintenance Veliparib and Temozolomide, in Patients with Newly Diagnosed High-Grade Glioma (HGG) without H3 K27M or BRAFV600E Mutations||Pediatric CIRB||Available to Open|
|ACNS0221||COG||A Phase II Study of Conformal Radiotherapy In Patients with Low-Grade Gliomas||Pediatric CIRB||Completed|
|AALL07P4||COG||A Pilot Study of Intravenous EZN-2285 (SC-PEG E. coli L-asparaginase; IND# 100594) or Intravenous Oncaspar in the Treatment of Patients with High-Risk Acute Lymphoblastic Leukemia (ALL): A Limited Institution Pilot Study||Pediatric CIRB||Available to Open|