Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
|Study Number||Lead Group||Study Title||CIRB||Study Status|
|ACNS0334||COG||A Phase III Randomized Trial for the Treatment of Newly Diagnosed Supratentorial PNET and High Risk Medulloblastoma in Children < 36 months Old with Intensive Induction Chemotherapy with Methotrexate Followed by Consolidation with Stem Cell Rescue vs. the Same Therapy Without Methotrexate: A Phase III Group-Wide Study||Pediatric CIRB||Available to Open|
|10017||ETCTN||A Randomized Phase 2 Trial of Atezolizumab (MPDL3280A), SGI-110 and CDX-1401 Vaccine in Recurrent Ovarian Cancer||Adult CIRB - Early Phase Emphasis||Available to Open|
|ACNS0927||COG||A Phase 1/2 Study of Suberoylanilide Hydroxamic Acid (SAHA; Vorinostat) and Local Irradiation; Followed By Maintenance SAHA in Children with Newly Diagnosed Diffuse Intrinsic Pontine Gliomas (DIPG)||Pediatric CIRB||Available to Open|
|LungMAP||SWOG||A Master Protocol to Evaluate Biomarker-Driven Therapies and Immunotherapies in Previously-Treated Non-Small Cell Lung Cancer (Lung-MAP Screening Study)||Adult CIRB - Late Phase Emphasis||Available to Open|
|EAQ171CD||ECOG-ACRIN||Implementing a Virtual Tobacco Treatment in Community Oncology Practices: “Smoke Free Support Study 2.0”||Cancer Prevention and Control CIRB||Available to Open|
|AREN0532||COG||Treatment for Very Low and Standard Risk Favorable Histology Wilms Tumor: A Groupwide Phase III Study||Pediatric CIRB||Available to Open|
|EAF151||ECOG-ACRIN||Change in Relative Cerebral Blood Volume as a Biomarker for Early Response to Bevacizumab in Patients with Recurrent Glioblastoma||Adult CIRB - Late Phase Emphasis||Available to Open|
|AAML0531||COG||A Phase III Randomized Trial of Gemtuzumab Ozogamicin (Mylotarg) Combined with Conventional Chemotherapy for De Novo Acute Myeloid Leukemia (AML) in Children; Adolescents; and Young Adults||Pediatric CIRB||Available to Open|
|9922||ETCTN||A Phase 2 Study of Ibrutinib (PCI-32765) in Refractory Distant Metastatic Cutaneous Melanoma: Correlation of Biomarkers with Response and Resistance||Adult CIRB - Early Phase Emphasis||Available to Open|
|10287||ETCTN||A randomized Phase I/II trial of fulvestrant and abemaciclib in combination with copanlisib (FAC) versus fulvestrant and abemaciclib alone (FA) for endocrine-resistant, hormone receptor positive, HER2 negative metastatic breast cancer (FAC vs FA)||Adult CIRB - Early Phase Emphasis||Available to Open|