CIRB Studies

Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.

To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.

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Study Number Lead Group Study Title CIRB Study Status
S1507 SWOG A Phase II Trial of Trametinib with Docetaxel in Patients with Kras Mutation Positive Non-Small Cell Lung Cancer (NSCLC) and Progressive Disease Following One or Two Prior Systemic Therapies Adult CIRB - Late Phase Emphasis Available to Open
E5508 ECOG Randomized Phase III Study of Maintenance Therapy with Bevacizumab; Pemetrexed; or a Combination of Bevacizumab and Pemetrexed Following Carboplatin; Paclitaxel and Bevacizumab for Advanced Non-Squamous NSCLC Adult CIRB - Late Phase Emphasis Available to Open
UAZ2017-09-02 CLO-University of Arizona Clinical Study of Avmacol® for Detoxification of Tobacco Carcinogens in Heavy Smokers Cancer Prevention and Control CIRB Available to Open
ABTC-1802 ABTC A Phase II Study of Binimetinib in Combination with Encorafenib in Adults with Recurrent BRAF V600-Mutated High-Grade Astrocytoma or other Primary Brain Tumor Adult CIRB - Late Phase Emphasis Available to Open
GOG-0275 GOG A Phase III Randomized Trial of Pulse Actinomycin-D Versus Multi-Day Methotrexate for the Treatment of Low-Risk Gestational Trophoblastic Neoplasia Adult CIRB - Late Phase Emphasis Available to Open
NRG-GY003 NRG Phase II Randomized Trial of Nivolumab with or without Ipilimumab in Patients with Persistent or Recurrent Epithelial Ovarian; Primary Peritoneal or Fallopian Tube Cancer Adult CIRB - Early Phase Emphasis Available to Open
ARST0531 COG Randomized Study of Vincristine; Dactinomycin and Cyclophosphamide (VAC) versus VAC Alternating with Vincristine and Irinotecan (VI) for Patients with Intermediate-Risk Rhabdomyosarcoma (RMS): A Groupwide Phase III Study Pediatric CIRB Available to Open
S1702 SWOG A Phase II Study of Isatuximab (SAR650984) for Patients with Previously Treated AL Amyloidosis Adult CIRB - Late Phase Emphasis Available to Open
AALL07P1 COG A Phase II Pilot Trial of Bortezomib (PS-341; Velcade; IND# 58;443) in Combination with Intensive Re-Induction Therapy for Children with Relapsed Acute Lymphoblastic Leukemia (ALL) and Lymphoblastic Lymphoma (LL) Pediatric CIRB Available to Open
S1007 SWOG A Phase III; Randomized Clinical Trial of Standard Adjuvant Endocrine Therapy +/- Chemotherapy in Patients with 1-3 Positive Nodes; Hormone Receptor-Positive and HER2-Negative Breast Cancer with Recurrence Score (RS) of 25 or Less. RxPONDER: A Clinical Trial RX for Positive Node; Endocrine Responsive Breast Cancer Adult CIRB - Late Phase Emphasis Available to Open
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