CIRB Studies
Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number | Lead Group | Study Title | CIRB | Study Status |
|---|---|---|---|---|
| E6201 | ECOG | A Phase III; Randomized Study of Gemcitabine [fixed-dose rate infusion] and Oxaliplatin (NSC 266046) versus Gemcitabine [fixed-dose rate infusion] versus Gemcitabine [30-minute infusion] in Pancreatic Carcinoma | Adult CIRB - Late Phase Emphasis | Completed |
| NSABP-B-49 | NSABP | A Phase III Clinical Trial Comparing the Combination of Docetaxel Plus Cyclophosphamide to Anthracycline-Based Chemotherapy Regimens for Women with Node-Positive or High-Risk Node-Negative; HER2-Negative Breast Cancer | Adult CIRB - Late Phase Emphasis | Available to Open |
| EAE161 | ECOG-ACRIN | Perfusion CT to Predict Progression-free Survival and Response Rate in Bevacizumab and Paclitaxel Treatment of Platinum-Resistant Persistent or Recurrent Epithelial Ovarian, Fallopian Tube, or Peritoneal Carcinoma | Adult CIRB - Late Phase Emphasis | Available to Open |
| E4512 | ECOG | A Randomized Phase III Trial for Surgically Resected Early Stage Non-Small Cell Lung Cancer: Crizotinib versus Observation for Patients with Tumors Harboring the Anaplastic Lymphoma Kinase (ALK) Fusion Protein | Adult CIRB - Late Phase Emphasis | Available to Open |
| CALGB-90106 | CALGB | A Randomized Phase III Study of Paclitaxel; Ifosfamide and Cisplatin Versus Vinblastine; Ifosfamide and Cisplatin as Second-Line Therapy for Patients with Relapsed/Resistant Germ Cell Tumors | Adult CIRB - Late Phase Emphasis | Completed |
| CALGB-10603 | CALGB | A Phase III Randomized; Double-Blind Study of Induction (Daunorubicin/Cytarabine) and Consolidation (High-Dose Cytarabine) Chemotherapy + Midostaurin (PKC412) (IND #101261) or Placebo in Newly Diagnosed Patients < 60 Years of Age with FLT3 Mutated Acute Myeloid Leukemia (AML) | Adult CIRB - Late Phase Emphasis | Available to Open |
| NRG-BN005 | NRG | A Phase II Randomized Trial of Proton vs. Photon Therapy (IMRT) for Cognitive Preservation in Patients with IDH Mutant, Low to Intermediate Grade Gliomas | Adult CIRB - Late Phase Emphasis | Available to Open |
| EA2182 | ECOG-ACRIN | A Randomized Phase II Study of De-Intensified ChemoRadiation for Early-Stage Anal Squamous Cell Carcinoma (DECREASE) | Adult CIRB - Late Phase Emphasis | Available to Open |
| NRG-HN002 | NRG | A Randomized Phase II Trial for Patients with p16 Positive; Non-Smoking Associated; Locoregionally Advanced Oropharyngeal Cancer | Adult CIRB - Late Phase Emphasis | Available to Open |
| S1712 | SWOG | A Randomized Phase II Study of Ruxolitinib (NSC-752295) in Combination with BCR-ABL Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia (CML) Patients with Molecular Evidence of Disease | Adult CIRB - Late Phase Emphasis | Available to Open |