CIRB Studies
Below is the current list of studies covered by the CIRB. It includes both Available to Open and Completed studies. Study documents approved after July 1, 2013 for all covered studies are available on the CTSU website.
To request documents approved before July 1, 2013, please contact the CIRB Helpdesk.
| Study Number | Lead Group | Study Title | CIRB | Study Status |
|---|---|---|---|---|
| ACNS0232 | COG | Radiotherapy Alone vs. Chemotherapy Followed by Response-based Radiotherapy for Newly Diagnosed Primary CNS Germinoma: A Phase III Group-Wide Study | Pediatric CIRB | Completed |
| CALGB-49808 | CALGB | A 2 X 2 X 2 Factorial Randomized Phase III Trial of Multimodality Therapy Comparing 4 Cycles of Doxorubicin and Cyclophosphamide with or without Dexrazoxane (AC +/- Z) Followed by 12 Weeks of Weekly Paclitaxel with or without Trastuzumab (T H) Followed by Local Therapy Followed by 40 Weeks of Weekly Trastuzumab or none in Women with HER-2+ STAGE IIIA; IIIB or Regional Stage IV Breast Cancer **ADMINISTRATIVELY COMPLETED as of December 15; 2002** | Adult CIRB - Late Phase Emphasis | Completed |
| AAML0523 | COG | A Phase I/II Study of CLOLAR (Clofarabine; IND# 73;789) in Combination with Cytarabine in Pediatric Patients with Refractory/Relapsed Leukemia | Pediatric CIRB | Completed |
| AOST06P1 | COG | Feasibility and Dose Discovery Analysis of Zoledronic Acid with Concurrent Chemotherapy in the Treatment of Newly Diagnosed Metastatic Osteosarcoma: A Groupwide Pilot Study | Pediatric CIRB | Completed |
| S0309 | SWOG | Myeloma Specimen Repository Protocol Ancillary | Adult CIRB - Late Phase Emphasis | Completed |
| CALGB-30506 | CALGB | A Randomized Phase III Trial of Adjuvant Chemotherapy in Patients with Early Stage Non-Small Cell Lung Cancer Associated with Banking of Frozen Tumor Specimens and Collection of Gene Expression Profile Data | Adult CIRB - Late Phase Emphasis | Completed |
| NCIC-MA.27B | NCIC CTG | The Influence of Five Years of Adjuvant Anastrozole or Exemestane on bone Mineral Density in Postmenopausal Women with Primary Breast Cancer - A Companion Study to NCIC CTG MA.27 | Adult CIRB - Late Phase Emphasis | Completed |
| GOG-0277 | GOG | A Phase III Randomized Trial of Gemcitabine (NSC# 613327) Plus Docetaxel (NSC# 628503) Followed by Doxorubicin (NCS# 123127) versus Observation for Uterus-Limited; High Grade Uterine Leiomyosarcoma | Adult CIRB - Late Phase Emphasis | Completed |
| E4599 | ECOG | Randomized Phase II/III Trial of Paclitaxel plus Carboplatin With or Without Bevacizumab (NSC #704865) in Patients with Advanced Nonsquamous NSCLC | Adult CIRB - Late Phase Emphasis | Completed |
| NSABP-B-36 | NSABP | A Clinical Trial of Adjuvant Therapy Comparing Six Cycles of 5-Fluorouracil; Epirubicin and Cyclophosphamide (FEC) to Four Cycles of Adriamycin and Cyclophosphamide (AC) in Patients with Node-Negative Breast Cancer | Adult CIRB - Late Phase Emphasis | Completed |